Department of Natural Medicinal Chemistry and Pharmacognosy, School of Pharmacy, Qingdao University, Qingdao, Shandong 266021, People's Republic of China.
Department of Pharmacy, Qingdao Municipal Hospital, Qingdao, Shandong 266071, People's Republic of China.
J Agric Food Chem. 2021 Sep 29;69(38):11216-11224. doi: 10.1021/acs.jafc.1c03513. Epub 2021 Sep 19.
Six new xanthone dimers, diaporxanthones A-F (-), and an unusual xanthone monomer diaporxanthone G (), in addition to seven known analogues (-), were isolated and identified from endophytic L17 harbored in the fruits of the salt-tolerant plant . The chemical structures of these metabolites were elucidated on the basis of nuclear magnetic resonance, high-resolution electrospray ionization mass spectrometry, and reported data in the literature. Their absolute configurations were established by single-crystal X-ray diffraction analysis together with time-dependent density functional theory electronic circular dichroism calculations. Among these compounds, compounds and exhibited moderate antifungal activities against sp. and and compound showed significant cytotoxicity against all selected five cancer cell lines.
从耐盐植物果实内生 L17 中分离得到 6 个新的二蒽酮二聚体（-），即 diaporxanthones A-F，以及一个不寻常的二蒽酮单体 diaporxanthone G ()，此外还分离得到了 7 个已知类似物 (-)。基于核磁共振、高分辨电喷雾电离质谱和文献报道的数据，解析了这些代谢产物的化学结构。通过单晶 X 射线衍射分析结合时间依赖的密度泛函理论电子圆二色谱计算确定了它们的绝对构型。在这些化合物中，化合物 和 对 sp. 和 表现出中等的抗真菌活性，而化合物 对所有选定的 5 种癌细胞系均显示出显著的细胞毒性。
