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抗菌水凝胶敷料的研究进展

Progress in Antibacterial Hydrogel Dressing.

作者信息

Liu Jie, Jiang Wenqi, Xu Qianyue, Zheng Yongjie

机构信息

College of Light Industry and Textile, Qiqihar University, Qiqihar 161006, China.

Engineering Research Center for Hemp and Product in Cold Region of Ministry of Education, Qiqihar 161006, China.

出版信息

Gels. 2022 Aug 12;8(8):503. doi: 10.3390/gels8080503.


DOI:10.3390/gels8080503
PMID:36005104
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9407327/
Abstract

Antibacterial hydrogel has excellent antibacterial property and good biocompatibility, water absorption and water retention, swelling, high oxygen permeability, etc.; therefore, it widely applied in biomedicine, intelligent textiles, cosmetics, and other fields, especially for medical dressing. As a wound dressing, the antibacterial hydrogel has the characteristics of absorbing wound liquid, controlling drug release, being non-toxic, being without side effects, and not causing secondary injury to the wound. Its preparation method is simple, and can crosslink via covalent or non-covalent bond, such as γ-radiation croFsslinking, free radical polymerization, graft copolymerization, etc. The raw materials are easy to obtain; usually these include chondroitin sulfate, sodium alginate, polyvinyl alcohol, etc., with different raw materials being used for different antibacterial modes. According to the hydrogel matrix and antibacterial mode, the preparation method, performance, antibacterial mechanism, and classification of antibacterial hydrogels are summarized in this paper, and the future development direction of the antibacterial hydrogel as wound dressing is proposed.

摘要

抗菌水凝胶具有优异的抗菌性能、良好的生物相容性、吸水性和保水性、溶胀性、高透氧性等;因此,它广泛应用于生物医学、智能纺织品、化妆品等领域,尤其用于医用敷料。作为伤口敷料,抗菌水凝胶具有吸收伤口渗出液、控制药物释放、无毒、无副作用且不会对伤口造成二次损伤的特点。其制备方法简单,可通过共价键或非共价键交联,如γ射线辐射交联、自由基聚合、接枝共聚等。原料易于获得;通常包括硫酸软骨素、海藻酸钠、聚乙烯醇等,不同的原料用于不同的抗菌模式。本文根据水凝胶基质和抗菌模式,对抗菌水凝胶的制备方法、性能、抗菌机制及分类进行了综述,并提出了抗菌水凝胶作为伤口敷料的未来发展方向。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fe8/9407327/9632ba380000/gels-08-00503-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fe8/9407327/bf98ce9e9f93/gels-08-00503-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fe8/9407327/6146c0e1469b/gels-08-00503-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fe8/9407327/b49fc5a5ec58/gels-08-00503-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fe8/9407327/dcfcf060d25f/gels-08-00503-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fe8/9407327/6fccc4ec68a9/gels-08-00503-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fe8/9407327/8479efd8eaa7/gels-08-00503-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fe8/9407327/04428799f2ae/gels-08-00503-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fe8/9407327/0e9d2cf8d26b/gels-08-00503-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fe8/9407327/57e794c581ea/gels-08-00503-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fe8/9407327/9632ba380000/gels-08-00503-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fe8/9407327/bf98ce9e9f93/gels-08-00503-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fe8/9407327/6146c0e1469b/gels-08-00503-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fe8/9407327/b49fc5a5ec58/gels-08-00503-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fe8/9407327/dcfcf060d25f/gels-08-00503-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fe8/9407327/6fccc4ec68a9/gels-08-00503-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fe8/9407327/8479efd8eaa7/gels-08-00503-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fe8/9407327/04428799f2ae/gels-08-00503-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fe8/9407327/0e9d2cf8d26b/gels-08-00503-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fe8/9407327/57e794c581ea/gels-08-00503-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fe8/9407327/9632ba380000/gels-08-00503-g010.jpg

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本文引用的文献

[1]
Improved mechanical properties of antimicrobial poly(-[3-(dimethylaminopropyl)] methacrylamide) hydrogels prepared by free radical polymerization in the presence of cetyltrimethylammonium bromide as a lyotropic liquid crystal template.

Soft Matter. 2022-6-1

[2]
Metronidazole-loaded gold nanoparticles in natural rubber latex as a potential wound dressing.

Int J Biol Macromol. 2022-6-30

[3]
A biocompatible PAA-Cu-MOP hydrogel for wound healing.

RSC Adv. 2020-10-1

[4]
A freeze-thaw PVA hydrogel loaded with guava leaf extract: physical and antibacterial properties.

RSC Adv. 2021-9-9

[5]
Photosensitizer-loaded hydrogels for photodynamic inactivation of multirestistant bacteria in wounds.

RSC Adv. 2021-2-17

[6]
Conductive Adhesive and Antibacterial Zwitterionic Hydrogel Dressing for Therapy of Full-Thickness Skin Wounds.

Front Bioeng Biotechnol. 2022-2-24

[7]
Dendritic Hydrogels with Robust Inherent Antibacterial Properties for Promoting Bacteria-Infected Wound Healing.

ACS Appl Mater Interfaces. 2022-3-9

[8]
Silk Hydrogel Electrostatically Functionalized with a Polycationic Antimicrobial Peptide: Molecular Interactions, Gel Properties, and Antimicrobial Activity.

Langmuir. 2022-1-11

[9]
Preparation of silane-dispersed graphene crosslinked vinyl carboxymethyl chitosan temperature-responsive hydrogel with antibacterial properties.

Int J Biol Macromol. 2022-3-1

[10]
Silk Fibroin Crosslinked Glycyrrhizic Acid and Silver Hydrogels for Accelerated Bacteria-Infected Wound Healing.

Macromol Biosci. 2022-4

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