角膜植入物表面的纳米工程：迈向功能性抗菌和生物膜材料
Nanoengineering the surface of corneal implants: towards functional anti-microbial and biofilm materials.
作者信息
Khatoon Zohra, Guzmán-Soto Irene, McTiernan Christopher D, Lazurko Caitlin, Simpson Fiona, Zhang Li, Cortes David, Mah Thien-Fah, Griffith May, Alarcon Emilio I
机构信息
Division of Cardiac Surgery, University of Ottawa Heart Institute 40 Ruskin Street Ottawa Canada
Centre de Recherche Hôpital Maisonneuve-Rosemont Montréal QC Canada
出版信息
RSC Adv. 2020 Jun 22;10(40):23675-23681. doi: 10.1039/d0ra03659e. eCollection 2020 Jun 19.
We report the development and use of a light-mediated grafting technology for the surface modification of biosynthetic corneal implants with peptide-capped nanoparticles (15-65 nm). The resulting materials have antimicrobial properties in bacterial suspension and also reduced the extent of biofilm formation. Our grafting technology offers a rapid route for the introduction of antimicrobial properties to premoulded corneal implants, and potentially other soft implant targets.
我们报告了一种光介导的接枝技术的开发与应用，该技术用于用肽封端的纳米颗粒（15 - 65纳米）对生物合成角膜植入物进行表面改性。所得材料在细菌悬浮液中具有抗菌性能，并且还降低了生物膜形成的程度。我们的接枝技术为将抗菌性能引入预成型角膜植入物以及潜在的其他软植入物靶点提供了一条快速途径。
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