Zhen Gao, Yingying Liu, Jingcheng Dong
Department of Integrated Traditional Chinese and Western Medicine, Huashan Hospital Affiliated to Fudan University, Shanghai, China.
Department of Retired Veteran Cadres, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Front Pharmacol. 2022 Apr 20;13:820086. doi: 10.3389/fphar.2022.820086. eCollection 2022.
To analyze all chronic obstructive pulmonary disease (COPD) drugs-related articles that were indexed in the Web of Science Core Collection (WOSCC) database until August 28, 2021 using bibliometric analysis, in order to provide a reliable reference for the treatment of COPD. A comprehensive search was conducted to analyze all COPD drugs-related articles using WOSCC database from inception to August 28, 2021. Abstracts and potentially eligible articles, which were retrieved during literature search, were screened by two reviewers. Besides, the CiteSpace (5.8.R1) software was utilized to analyze the overall structure of the network, the network clusters, the links between clusters, the key nodes or pivot points, and the pathways. A total of 2552 COPD-drugs related articles were retrieved. From the perspective of categorization of published articles based on country, the United States is the country with the largest number of published articles and completed clinical trials, highlighting the important role of this country in the treatment of COPD. However, in terms of the proportion of ongoing clinical trials, China has the highest proportion, suggesting that China will play a more pivotal role in the medication of COPD in the future. From the perspective of cooperation among countries, the cooperation among European countries was closer than that among Asian countries. In the recent three decades, the top 20 institutions, with a particular concentration on the treatment of COPD, were from North America and Europe. The co-citation analysis showed that, among 2,552 articles, 53154 citations were recorded, and the co-citation network indicated that 24 clusters could be achieved. The administration of bronchodilators and pulmonary drug delivery systems, as well as consideration of elderly COPD patients remained the hotspots, while triple therapy and comorbidity of COPD, as well as the prevention and treatment of elderly COPD patients had been frontiers in recent years.
利用文献计量分析法分析截至2021年8月28日在科学网核心合集（WOSCC）数据库中索引的所有慢性阻塞性肺疾病（COPD）药物相关文章，以便为COPD的治疗提供可靠参考。使用WOSCC数据库对所有COPD药物相关文章进行全面检索，检索时间从建库至2021年8月28日。两名评审员对文献检索过程中检索到的摘要和可能符合条件的文章进行筛选。此外，利用CiteSpace（5.8.R1）软件分析网络的整体结构、网络聚类、聚类之间的联系、关键节点或枢纽点以及路径。共检索到2552篇COPD药物相关文章。从发表文章的国家分类角度来看，美国是发表文章数量最多且完成临床试验数量最多的国家，凸显了该国在COPD治疗中的重要作用。然而，就正在进行的临床试验比例而言，中国的比例最高，这表明中国未来在COPD药物治疗中将发挥更关键的作用。从国家间合作角度来看，欧洲国家之间的合作比亚洲国家之间的合作更为紧密。在最近三十年里，排名前20的机构尤其专注于COPD的治疗，这些机构来自北美和欧洲。共被引分析表明，在2552篇文章中，记录了53154次引用，共被引网络显示可以实现24个聚类。支气管扩张剂和肺部给药系统的管理以及对老年COPD患者的关注仍然是热点，而三联疗法和COPD的合并症以及老年COPD患者的预防和治疗近年来一直是前沿领域。
