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基于网络药理学和代谢组学整合分析揭示四物汤治疗化疗药物致再生障碍性贫血的潜在作用机制。

Integrated Network Pharmacology and Metabolomics Analysis to Reveal the Potential Mechanism of Siwu Paste on Aplastic Anemia Induced by Chemotherapy Drugs.

机构信息

Hunan Academy of Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan, 410013, People's Republic of China.

Hunan Times Sunshine Pharmaceutical Co., Ltd., Changsha, Hunan, 425007, People's Republic of China.

出版信息

Drug Des Devel Ther. 2022 Apr 28;16:1231-1254. doi: 10.2147/DDDT.S327433. eCollection 2022.

DOI:10.2147/DDDT.S327433
PMID:35517983
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9061215/
Abstract

PURPOSE

This study aimed to reveal the multicomponent synergy mechanisms of SWP based on network pharmacology and metabolomics for exploring the relationships of active ingredients, biological targets, and crucial metabolic pathways.

MATERIALS

Network pharmacology, including TRRUST, GO, and KEGG, enrichment was used to discover the active ingredients and potential regulation mechanisms of SWP. LC-MS and multivariate data analysis method were further applied to analyze serum metabolomics profiling for discovering the potential metabolic mechanisms of SWP on AA induced by Cyclophosphamide (CTX) and 1-Acetyl-2-phenylhydrazine (APH).

RESULTS

A total of 27 important bioactive ingredients meeting the ADME (absorption, distribution, metabolism, and excretion) screening criteria from SWP were selected. Interaction networks were constructed and validated based on the 10 associated ingredients with the relevant targets. A total of 125 biomarkers were found by Metabolomics approach, which associated with the development of AA, mainly involved in amino acid metabolism and lipid metabolism. While SWP can reverse the above 12 metabolites changed by AA. Network analysis revealed the synergistic effects of SWP through the 43 crucial pathways, including Sphingolipid signaling pathway, Sphingolipid metabolism, Arginine and proline metabolism, VEGF signaling pathway, Estrogen signaling pathway.

CONCLUSION

The study suggested that SWP is a useful alternative for the treatment of AA induced by CTX + APH. Its potential mechanisms are to improve hematopoietic microenvironment and promote bone marrow hematopoiesis therapies.

摘要

目的

本研究旨在基于网络药理学和代谢组学揭示 SWP 的多成分协同作用机制，以探索活性成分、生物靶标和关键代谢途径之间的关系。

材料

网络药理学，包括 TRRUST、GO 和 KEGG 富集，用于发现 SWP 的活性成分和潜在调节机制。进一步应用 LC-MS 和多变量数据分析方法分析血清代谢组学谱，以发现 SWP 对环磷酰胺（CTX）和 1-乙酰基-2-苯基肼（APH）诱导的 AA 的潜在代谢机制。

结果

从 SWP 中选择了 27 种符合 ADME（吸收、分布、代谢和排泄）筛选标准的重要生物活性成分。基于与相关靶标相关的 10 种成分构建和验证了相互作用网络。代谢组学方法共发现 125 种生物标志物，与 AA 的发生发展有关，主要涉及氨基酸代谢和脂质代谢。而 SWP 可以逆转 AA 引起的上述 12 种代谢物的变化。网络分析揭示了 SWP 通过 43 个关键途径的协同作用，包括鞘脂信号通路、鞘脂代谢、精氨酸和脯氨酸代谢、VEGF 信号通路、雌激素信号通路。

结论

该研究表明，SWP 是治疗 CTX+APH 诱导的 AA 的有效替代药物。其潜在机制是改善造血微环境，促进骨髓造血治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41b4/9061215/4d3f09474871/DDDT-16-1231-g0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41b4/9061215/2910c99ced26/DDDT-16-1231-g0001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41b4/9061215/623c24ee08d1/DDDT-16-1231-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41b4/9061215/efc5e5d02ea7/DDDT-16-1231-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41b4/9061215/727b6f35c1bf/DDDT-16-1231-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41b4/9061215/4d3f09474871/DDDT-16-1231-g0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41b4/9061215/2910c99ced26/DDDT-16-1231-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41b4/9061215/649180a6a3db/DDDT-16-1231-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41b4/9061215/6f07d4acb8fd/DDDT-16-1231-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41b4/9061215/fb323e8b3deb/DDDT-16-1231-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41b4/9061215/623c24ee08d1/DDDT-16-1231-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41b4/9061215/efc5e5d02ea7/DDDT-16-1231-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41b4/9061215/727b6f35c1bf/DDDT-16-1231-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41b4/9061215/4d3f09474871/DDDT-16-1231-g0008.jpg

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