Kierkegaard-Hansen A, Pedersen E B, Darling S, Amdisen A
Int Pharmacopsychiatry. 1978;13(3):133-7. doi: 10.1159/000468333.
Plasma renin concentration was determined in patients given lithium treatment. In longitudinal study plasma renin concentration was determined in nine patients before the start of lithium treatment and at intervals during 3 months of treatment. In a transversal study, 18 patients given lithium treatment for 2--20 years were compared with 11 control persons. In the longitudinal study, plasma renin concentrations did not, during lithium treatment, deviate significantly from pre-treatment values. In the transversal study, values in the lithium treated patients did not differ significantly from values in the control group. There were no correlations, in the transversal study, between serum lithium concentrations and plasma renin concentrations. Our study indicates that the plasma renin concentration remains unaffected by lithium administered in nontoxic doses.
对接受锂治疗的患者测定了血浆肾素浓度。在纵向研究中，对9名患者在开始锂治疗前及治疗3个月期间每隔一段时间测定血浆肾素浓度。在横向研究中，将18名接受锂治疗2至20年的患者与11名对照者进行了比较。在纵向研究中，锂治疗期间血浆肾素浓度与治疗前值相比无显著偏差。在横向研究中，接受锂治疗患者的值与对照组的值无显著差异。在横向研究中，血清锂浓度与血浆肾素浓度之间无相关性。我们的研究表明，无毒剂量的锂给药不会影响血浆肾素浓度。
