Kierkegaard-Hansen A, Pedersen E B, Darling S, Amdisen A
Int Pharmacopsychiatry. 1977;12(4):210-4. doi: 10.1159/000468310.
Inspired from experiments in animals, plasma renin substrate was determined in patients given lithium treatment. In a longitudinal study, renin substrate was determined in 9 patients before the start of lithium treatment and at intervals during 3 months of treatment. In a transversal study, 18 patients on lithium treatment for 2--20 years were compared with 11 control persons. In the longitudinal study, plasma renin substrate values did not, during lithium treatment, deviate significantly from pretreatment values. In the transversal study, values in the lithium-treated patients did not differ significantly from values in the control group. There were no correlations between serum lithium concentrations and plasma renin substrate values. Our study indicates that plasma renin substrate remains unaffected by lithium treatment of manic-depressive patients.
受动物实验启发，对接受锂盐治疗的患者测定了血浆肾素底物。在一项纵向研究中，对9例患者在开始锂盐治疗前及治疗3个月期间的不同时间点测定了肾素底物。在一项横向研究中，将18例接受锂盐治疗2至20年的患者与11名对照者进行了比较。在纵向研究中，锂盐治疗期间血浆肾素底物值与治疗前值相比无显著偏差。在横向研究中，接受锂盐治疗患者的值与对照组的值无显著差异。血清锂浓度与血浆肾素底物值之间无相关性。我们的研究表明，锂盐治疗躁郁症患者时血浆肾素底物不受影响。
