Kierkegaard-Hansen A, Pedersen E B, Darling S, Amdisen A
Int Pharmacopsychiatry. 1977;12(1):49-53. doi: 10.1159/000468285.
Plasma renin activity (PRA) was determined in patients given lithium treatment. In a longitudinal study PRA was determined in 9 patients before the start of lithium treatment and at intervals during 3 months of treatment. The activity was increased significantly above pretreatment values on day 8 of the treatment; thereafter it fell to pretreatment values. In a transversal study 18 patients given lithium treatment for 2-20 years were compared with 11 control persons. PRA did not differ significantly between the two groups. The results indicate that PRA rises transiently shortly after start of lithium treatment and thereafter falls to pretreatment values where it remains even under prolonged lithium administration.
对接受锂治疗的患者测定了血浆肾素活性（PRA）。在一项纵向研究中，对9名患者在开始锂治疗前以及治疗3个月期间的不同时间点测定了PRA。治疗第8天时，活性显著高于治疗前值；此后又降至治疗前水平。在一项横向研究中，将18名接受锂治疗2至20年的患者与11名对照者进行了比较。两组之间的PRA没有显著差异。结果表明，锂治疗开始后不久PRA会短暂升高，此后降至治疗前水平，即使长期服用锂仍维持该水平。
