Alon U, Davidai G, Berant M, Merzbach D
Antimicrob Agents Chemother. 1987 Jan;31(1):126-8. doi: 10.1128/AAC.31.1.126.
We analyzed the antibiotic susceptibility of 5,348 urinary isolates of Escherichia coli, "Klebsiella aerogenes," and Proteus mirabilis grown in three laboratories from 1980 to 1985. A continuous rise in resistance to trimethoprim-sulfamethoxazole was observed; 63% of the strains from inpatients in 1984 and 51% of those from outpatients in 1985 were resistant to this drug. Isolates from outpatients in 1985 were mostly susceptible to nitrofurantoin (mean susceptibility, 92%) and to oral cephalosporins (mean susceptibility, 84%). As for isolates from inpatients, none of the antimicrobial agents now used was satisfactory for initial chemotherapy, indicating a need for new antibacterial strategies.
我们分析了1980年至1985年在三个实验室培养的5348株大肠埃希菌、产气克雷伯菌和奇异变形杆菌的尿液分离株的抗生素敏感性。观察到对甲氧苄啶-磺胺甲恶唑的耐药性持续上升；1984年住院患者的菌株中有63%以及1985年门诊患者的菌株中有51%对该药物耐药。1985年门诊患者的分离株大多对呋喃妥因敏感（平均敏感性为92%）和口服头孢菌素敏感（平均敏感性为84%）。至于住院患者的分离株，目前使用的抗菌药物中没有一种对初始化疗令人满意，这表明需要新的抗菌策略。
