Dyer I E, Sankary T M, Dawson J A
Department of Epidemiology, UCLA School of Public Health, USA.
West J Med. 1998 Nov;169(5):265-8.
This study assessed changing patterns of antibiotic resistance in Escherichia coli urinary tract infections at a university student health center during three periods: the first 6 months each of 1991, 1994, and 1997. Urine culture and sensitivity results were taken from available medical records of female patients having urine cultures during the three periods (1991, n = 739; 1994, n = 938; 1997, n = 863); age and ethnicity were also noted. In E. coli isolates (the majority of positive cultures), resistance to four antibiotics changed significantly: ampicillin (30% to 45% to 39%), carbenicillin (29% to 42% to 39%), tetracycline (29% to 40% to 23%), and trimethoprim/sulfamethoxazole (15% to 32% to 15%). The results raise questions regarding the future clinical reliability of several commonly used antibiotics in the treatment of urinary tract infection.
本研究评估了在一所大学生健康中心，1991年、1994年和1997年的前6个月这三个时间段内，大肠杆菌尿路感染中抗生素耐药性的变化模式。尿培养和药敏结果取自这三个时间段内进行尿培养的女性患者的现有病历（1991年，n = 739；1994年，n = 938；1997年，n = 863）；同时记录了年龄和种族。在大肠杆菌分离株（大多数阳性培养物）中，对四种抗生素的耐药性发生了显著变化：氨苄西林（从30%升至45%，再降至39%）、羧苄西林（从29%升至42%，再降至39%）、四环素（从29%升至40%，再降至23%）以及甲氧苄啶/磺胺甲恶唑（从15%升至32%，再降至15%）。这些结果引发了关于几种常用抗生素在治疗尿路感染方面未来临床可靠性的问题。
