用基于硼酸盐的比率荧光探针观察对乙酰氨基酚过量后小鼠肝脏中过氧亚硝酸盐的生成。
Observation of the generation of peroxynitrite in mouse liver after acetaminophen overdose with a boronate-based ratiometric fluorescence probe.
作者信息
Ma Ying, Tian Haigang, Jin Zhengyu, Li Xiaoyong, Li Yiping
机构信息
School of Pharmacy, Health Science Center, Xi'an Jiaotong University Xi'an 710061 Shaanxi China
School of Science, Xi'an Jiaotong University Xi'an 710061 Shaanxi China
出版信息
RSC Adv. 2019 Feb 25;9(12):6510-6514. doi: 10.1039/c8ra10053e. eCollection 2019 Feb 22.
A ratiometric fluorescent probe, BTPB, for the selective monitoring of hepatic peroxynitrite (ONOO) after acetaminophen (APAP) overdose has been developed. Our study provided direct evidence for supporting the generation of ONOO in APAP-induced liver injury. This new probe will be a useful tool for studying the roles of ONOO .
一种用于对乙酰氨基酚（APAP）过量服用后肝脏中过氧亚硝酸盐（ONOO）进行选择性监测的比率荧光探针BTPB已被开发出来。我们的研究为支持APAP诱导的肝损伤中ONOO的产生提供了直接证据。这种新型探针将成为研究ONOO作用的有用工具。
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