Draganov Alexander B, Wang Ke, Holmes Jalisa, Damera Krishna, Wang Danzhu, Dai Chaofeng, Wang Binghe
Department of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, 30303-3965, Georgia, USA.
Chem Commun (Camb). 2015 Oct 21;51(82):15180-3. doi: 10.1039/c5cc05890b.
The feasibility of a neighboring boronic acid-facilitated facile condensation of an aldehyde is described. This reaction is bio-orthogonal, complete at room temperature within minutes, and suitable for bioconjugation chemistry. The boronic acid group serves the dual purpose of catalyzing the condensation reaction and being a handle for secondary functionalization.
本文描述了一种邻位硼酸促进醛的简便缩合反应的可行性。该反应具有生物正交性，在室温下几分钟内即可完成，适用于生物共轭化学。硼酸基团具有催化缩合反应和作为二次功能化手柄的双重作用。
