Meinhardt Anna-Lena, Sandifer Christopher W, Dave Manish
Internal Medicine, Rutgers University New Jersey Medical School, Newark, USA.
Hematology and Medical Oncology, Cooperman Barnabas Medical Center, Livingston, USA.
Cureus. 2022 Apr 2;14(4):e23767. doi: 10.7759/cureus.23767. eCollection 2022 Apr.
Multiple myeloma is a neoplastic disease of plasma cells. Plasma cell disorders can present as a single lesion (solitary plasmacytoma) or as multiple lesions (multiple myeloma). Solitary plasmacytomas can occur in bone (plasmacytoma of bone) or in soft tissues (extramedullary plasmacytoma), and both can serve as a precursor lesion to multiple myeloma. These lesions may occur anywhere, however, intracranial presentations are rare. Here, we present a rare case of solitary intracranial extramedullary plasmacytoma in a patient complaining of headaches and vision changes. Despite radiation treatment, intracranial progression and rare lymph node involvement were seen soon after, prompting myeloma-directed therapy followed by autologous stem cell transplant, which have resulted in remission to date.
多发性骨髓瘤是一种浆细胞的肿瘤性疾病。浆细胞疾病可表现为单个病灶（孤立性浆细胞瘤）或多个病灶（多发性骨髓瘤）。孤立性浆细胞瘤可发生于骨骼（骨浆细胞瘤）或软组织（髓外浆细胞瘤），两者均可作为多发性骨髓瘤的前驱病变。这些病变可发生于任何部位，然而，颅内表现较为罕见。在此，我们报告一例罕见的孤立性颅内髓外浆细胞瘤病例，患者主诉头痛和视力改变。尽管进行了放射治疗，但随后很快出现颅内进展和罕见的淋巴结受累，促使采用针对骨髓瘤的治疗，随后进行自体干细胞移植，迄今为止已实现缓解。
