负载于MIL-53(Al)中的磺胺嘧啶作为一种杀菌剂局部给药系统。
Sulfadiazine hosted in MIL-53(Al) as a biocide topical delivery system.
作者信息
Águila-Rosas Javier, Quirino-Barreda Tomás, Leyva-Gómez Gerardo, González-Zamora Eduardo, Ibarra Ilich A, Lima Enrique
机构信息
Laboratorio de Farmacia Molecular y Liberación Controlada, UAM-Xochimilco Calzada del Hueso 1100, Col. Villa Quietud CP 04960 CDMX Mexico.
Doctorado en Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana, UAM-Xochimilco Calzada del Hueso 1100, Col. Villa Quietud CP 04960, CDMX Mexico.
出版信息
RSC Adv. 2020 Jul 7;10(43):25645-25651. doi: 10.1039/d0ra03636f. eCollection 2020 Jul 3.
Sulfadiazine (SDZ), a bacteriostatic agent, was hosted in a metal-organic framework, specifically in MIL-53(Al) and modified-zinc MIL-53(Al,Zn). Materials were characterized structural, and texturally. Both hosts loaded sulfadiazine but they were differenced regarding the release of sulfadiazine. The presence of zinc plays a significant role to the modulation of sulfadiazine-MOF interactions. Release of sulfadiazine from sulfadiazine@MOFs was monitored and conditions. A kinetic release model is proposed for sulfadiazine release. Remarkably, the materials did not show cytotoxicity against eukaryote cells.
磺胺嘧啶（SDZ）是一种抑菌剂，被负载于金属有机框架材料中，具体为MIL-53(Al)和改性锌MIL-53(Al,Zn)。对这些材料进行了结构和纹理表征。两种载体都负载了磺胺嘧啶，但在磺胺嘧啶的释放方面存在差异。锌的存在对磺胺嘧啶与金属有机框架相互作用的调节起着重要作用。监测了磺胺嘧啶从磺胺嘧啶@金属有机框架材料中的释放情况及条件。提出了磺胺嘧啶释放的动力学模型。值得注意的是，这些材料对真核细胞没有显示出细胞毒性。
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