Materials Science and Technology Program, College of Arts and Sciences, Qatar University, Doha, Qatar,
Department of Chemistry, State Key Laboratory of Molecular Engineering of Polymers, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, iChEM, Fudan University, Shanghai, People's Republic of China.
Int J Nanomedicine. 2019 Mar 6;14:1707-1723. doi: 10.2147/IJN.S193981. eCollection 2019.
Magnetic core-shell nanocarriers have been attracting growing interest owing to their physicochemical and structural properties. The main principles of magnetic nanoparticles (MNPs) are localized treatment and stability under the effect of external magnetic fields. Furthermore, these MNPs can be coated or functionalized to gain a responsive property to a specific trigger, such as pH, heat, or even enzymes. Current investigations have been focused on the employment of this concept in cancer therapies. The evaluation of magnetic core-shell materials includes their magnetization properties, toxicity, and efficacy in drug uptake and release. This review discusses some categories of magnetic core-shell drug carriers based on FeO and FeO as the core, and different shells such as poly(lactic-co-glycolic acid), poly(vinylpyrrolidone), chitosan, silica, calcium silicate, metal, and lipids. In addition, the review addresses their recent potential applications for cancer treatment.
磁性核壳纳米载体由于其物理化学和结构特性而引起了越来越多的关注。磁性纳米粒子 (MNP) 的主要原理是在外部磁场的作用下进行局部治疗和稳定性。此外，这些 MNP 可以进行涂层或功能化，以获得对特定触发因素的响应特性，例如 pH 值、热量甚至酶。目前的研究重点是将这一概念应用于癌症治疗。对磁性核壳材料的评估包括其磁化特性、毒性以及在药物摄取和释放方面的功效。本文综述了一些基于 FeO 和 FeO 作为核的磁性核壳药物载体类别，以及不同的壳，如聚（乳酸-共-乙醇酸）、聚（乙烯基吡咯烷酮）、壳聚糖、二氧化硅、硅酸钙、金属和脂质。此外，本文还讨论了它们在癌症治疗中的最新潜在应用。
