文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期，新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

用于响应型和靶向药物输送系统的磁性核壳载体的展望。

A perspective on magnetic core-shell carriers for responsive and targeted drug delivery systems.

机构信息

Materials Science and Technology Program, College of Arts and Sciences, Qatar University, Doha, Qatar,

Department of Chemistry, State Key Laboratory of Molecular Engineering of Polymers, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, iChEM, Fudan University, Shanghai, People's Republic of China.

出版信息

Int J Nanomedicine. 2019 Mar 6;14:1707-1723. doi: 10.2147/IJN.S193981. eCollection 2019.

DOI:10.2147/IJN.S193981
PMID:30880975
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6408922/
Abstract

Magnetic core-shell nanocarriers have been attracting growing interest owing to their physicochemical and structural properties. The main principles of magnetic nanoparticles (MNPs) are localized treatment and stability under the effect of external magnetic fields. Furthermore, these MNPs can be coated or functionalized to gain a responsive property to a specific trigger, such as pH, heat, or even enzymes. Current investigations have been focused on the employment of this concept in cancer therapies. The evaluation of magnetic core-shell materials includes their magnetization properties, toxicity, and efficacy in drug uptake and release. This review discusses some categories of magnetic core-shell drug carriers based on FeO and FeO as the core, and different shells such as poly(lactic-co-glycolic acid), poly(vinylpyrrolidone), chitosan, silica, calcium silicate, metal, and lipids. In addition, the review addresses their recent potential applications for cancer treatment.

摘要

磁性核壳纳米载体由于其物理化学和结构特性而引起了越来越多的关注。磁性纳米粒子 (MNP) 的主要原理是在外部磁场的作用下进行局部治疗和稳定性。此外，这些 MNP 可以进行涂层或功能化，以获得对特定触发因素的响应特性，例如 pH 值、热量甚至酶。目前的研究重点是将这一概念应用于癌症治疗。对磁性核壳材料的评估包括其磁化特性、毒性以及在药物摄取和释放方面的功效。本文综述了一些基于 FeO 和 FeO 作为核的磁性核壳药物载体类别，以及不同的壳，如聚（乳酸-共-乙醇酸）、聚（乙烯基吡咯烷酮）、壳聚糖、二氧化硅、硅酸钙、金属和脂质。此外，本文还讨论了它们在癌症治疗中的最新潜在应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8499/6408922/35bafbb68629/ijn-14-1707Fig9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8499/6408922/5223e8a268b0/ijn-14-1707Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8499/6408922/df5509c94fe5/ijn-14-1707Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8499/6408922/4b765d0a3ae2/ijn-14-1707Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8499/6408922/23952172e005/ijn-14-1707Fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8499/6408922/19007d46ff22/ijn-14-1707Fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8499/6408922/f3d3f46a4e35/ijn-14-1707Fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8499/6408922/e92d593b0dfb/ijn-14-1707Fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8499/6408922/e36a4621e67d/ijn-14-1707Fig8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8499/6408922/35bafbb68629/ijn-14-1707Fig9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8499/6408922/5223e8a268b0/ijn-14-1707Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8499/6408922/df5509c94fe5/ijn-14-1707Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8499/6408922/4b765d0a3ae2/ijn-14-1707Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8499/6408922/23952172e005/ijn-14-1707Fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8499/6408922/19007d46ff22/ijn-14-1707Fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8499/6408922/f3d3f46a4e35/ijn-14-1707Fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8499/6408922/e92d593b0dfb/ijn-14-1707Fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8499/6408922/e36a4621e67d/ijn-14-1707Fig8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8499/6408922/35bafbb68629/ijn-14-1707Fig9.jpg

相似文献

[1]
A perspective on magnetic core-shell carriers for responsive and targeted drug delivery systems.

Int J Nanomedicine. 2019-3-6

[2]
Multimodal Mesoporous Silica Nanocarriers for Dual Stimuli-Responsive Drug Release and Excellent Photothermal Ablation of Cancer Cells.

Int J Nanomedicine. 2020-10-8

[3]
Magnetic/NIR-thermally responsive hybrid nanogels for optical temperature sensing, tumor cell imaging and triggered drug release.

Nanoscale. 2014-11-7

[4]
Preparation of Porous γ-Fe2O3@mWO3 Multifunctional Nanoparticles for Drug Loading and Controlled Release.

Curr Drug Deliv. 2018-2-14

[5]
Magnetic core-shell nanoparticles for drug delivery by nebulization.

J Nanobiotechnology. 2013-1-23

[6]
pH sensitive core-shell magnetic nanoparticles for targeted drug delivery in cancer therapy.

Rom J Morphol Embryol. 2016

[7]
Facile Layer-by-Layer Self-Assembly toward Enantiomeric Poly(lactide) Stereocomplex Coated Magnetite Nanocarrier for Highly Tunable Drug Deliveries.

ACS Appl Mater Interfaces. 2016-1-27

[8]
Magnetic targeting and pH-microwave dual responsive Janus mesoporous silica nanoparticles for drug encapsulation and delivery.

Nanotechnology. 2024-5-16

[9]
Folic acid functionalized reduction-responsive magnetic chitosan nanocapsules for targeted delivery and triggered release of drugs.

Carbohydr Polym. 2017-3-29

[10]
Formation of oligonucleotide-gated silica shell-coated Fe₃O₄-Au core-shell nanotrisoctahedra for magnetically targeted and near-infrared light-responsive theranostic platform.

J Am Chem Soc. 2014-6-30

引用本文的文献

[1]
Development of Solid Nanosystem for Delivery of Chlorhexidine with Increased Antimicrobial Activity and Decreased Cytotoxicity: Characterization and In Vitro and In Ovo Toxicological Screening.

Molecules. 2025-1-3

[2]
Cancer treatment approaches within the frame of hyperthermia, drug delivery systems, and biosensors: concepts and future potentials.

RSC Adv. 2024-12-12

[3]
Iron-Based Nanoplatforms Achieve Hepatocellular Carcinoma Regression Through a Cascade of Effects.

Int J Nanomedicine. 2024

[4]
A Preliminary Report Regarding the Morphological Changes of Nano-Enabled Pharmaceutical Formulation on Human Lung Carcinoma Monolayer and 3D Bronchial Microtissue.

Medicina (Kaunas). 2024-1-25

[5]
Upscale Synthesis of Magnetic Mesoporous Silica Nanoparticles and Application to Metal Ion Separation: Nanosafety Evaluation.

Nanomaterials (Basel). 2023-12-16

[6]
How Magnetic Composites are Effective Anticancer Therapeutics? A Comprehensive Review of the Literature.

Int J Nanomedicine. 2023

[7]
Stimuli-responsive polymeric nanomaterials for rheumatoid arthritis therapy.

Biophys Rep. 2020-10-31

[8]
Superparamagnetic iron oxide nanoparticles for their application in the human body: Influence of the surface.

Heliyon. 2023-5-25

[9]
Smart and Multi-Functional Magnetic Nanoparticles for Cancer Treatment Applications: Clinical Challenges and Future Prospects.

Nanomaterials (Basel). 2022-10-12

[10]
Magnetic nanoparticles and magnetic particle spectroscopy-based bioassays: a 15 year recap.

Nano Futures. 2022-6

本文引用的文献

[1]
pH- and redox-triggered synergistic controlled release of a ZnO-gated hollow mesoporous silica drug delivery system.

J Mater Chem B. 2015-2-21

[2]
Outside-in stepwise functionalization of mesoporous silica nanocarriers for matrix type sustained release of fluoroquinolone drugs.

J Mater Chem B. 2015-3-14

[3]
Thermal Properties of TiO₂NP/CNT/LDPE Hybrid Nanocomposite Films.

Polymers (Basel). 2018-11-15

[4]
Recent Overviews in Functional Polymer Composites for Biomedical Applications.

Polymers (Basel). 2018-7-4

[5]
Multifunctional Magnetic Mesoporous Silica Nanoagents for Enzyme-Responsive Drug Delivery and MR Imaging.

Nanotheranostics. 2018-5-23

[6]
Recent advances in functional nanostructures as cancer photothermal therapy.

Int J Nanomedicine. 2018-5-17

[7]
Recyclable magnetic nanoparticles grafted with antimicrobial metallopolymer-antibiotic bioconjugates.

Biomaterials. 2018-5-3

[8]
Magnetic Mesoporous Calcium Sillicate/Chitosan Porous Scaffolds for Enhanced Bone Regeneration and Photothermal-Chemotherapy of Osteosarcoma.

Sci Rep. 2018-5-9

[9]
Dendrimers: From Design to Application-A Progress Report.

Angew Chem Int Ed Engl. 1999-4-1

[10]
Polymer-Based Electrospun Nanofibers for Biomedical Applications.

Nanomaterials (Basel). 2018-4-20

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索