Suraphan Nuntanit, Fan Linfeng, Liu Baoxia, Wu Decheng
Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences Beijing 100190 China
University of Chinese Academy of Sciences Beijing 100049 P. R. China.
RSC Adv. 2020 Jul 3;10(43):25418-25425. doi: 10.1039/d0ra03825c.
Improving drug utilization of water-based pesticide formulations is facile and feasible to efficiently avoid serious pesticide residues and reduce the resulting environmental pollution. A co-delivery system of two- or multi-pesticides within one formulation could enhance drug efficiency and decrease usage amounts of pesticides due to the synergistic effect of the loaded multiple pesticides. Herein, we reported a porous polylactide (PLA) microcapsule formulation for co-delivery of avermectin (Av) and chlorantraniliprole (CAP). A double emulsion method combined with premix membrane emulsion (PME) was adopted to produce the Av/CAP-loaded porous microcapsules (Av/CAP P-MCs) with prolonged drug release, high loading content and entrapment efficiency, as well as good light and thermal stability. Compared with single Av- or CAP-loaded microcapsule formulations, the Av/CAP P-MCs exhibited higher biotoxicity against . These results reveal that the Av/CAP co-delivery system may be a promising candidate to be further explored as a facile, effective and environmentally-friendly pesticide formulation.
提高水基农药制剂的药物利用率简便可行，可有效避免严重的农药残留并减少由此造成的环境污染。在一种制剂中两种或多种农药的共递送系统可提高药物效率，并由于负载的多种农药的协同作用而减少农药使用量。在此，我们报道了一种用于共递送阿维菌素（Av）和氯虫苯甲酰胺（CAP）的多孔聚乳酸（PLA）微胶囊制剂。采用双乳液法结合预混膜乳液（PME）制备了负载Av/CAP的多孔微胶囊（Av/CAP P-MCs），其具有延长的药物释放、高负载量和包封率，以及良好的光稳定性和热稳定性。与单一负载Av或CAP的微胶囊制剂相比，Av/CAP P-MCs对……表现出更高的生物毒性。这些结果表明，Av/CAP共递送系统可能是一种有前途的候选物，可作为一种简便、有效且环保的农药制剂进一步探索。
