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病例报告:在一只猫身上使用组织型纤溶酶原激活剂成功实现肺血栓栓塞再灌注

Case Report: Successful Reperfusion of Pulmonary Thromboembolism Using tPA in a Cat.

作者信息

Sutton Blake, Long Mays Erin, McLaughlin Chris

机构信息

Veterinary Specialty Services, St. Louis, MO, United States.

Department of Cardiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, United States.

出版信息

Front Vet Sci. 2022 Apr 20;9:851106. doi: 10.3389/fvets.2022.851106. eCollection 2022.

DOI:10.3389/fvets.2022.851106
PMID:35518636
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9067301/
Abstract

Pulmonary thromboembolism is a potentially life threatening condition that is uncommonly recognized in cats. Thrombolytic agents have been described as a treatment for this condition in human and canine patients, particularly in cases where hemodynamic instability is persistent despite supportive care. This report describes the clinical course, echocardiographic diagnosis, and successful thrombolysis of a cat with pulmonary thromboembolism. Despite confirmed reperfusion, the cat succumbed to thromboembolic disease highlighting the dearth of knowledge about optimal treatment of this disease process in small animals, particularly in cats.

摘要

肺血栓栓塞是一种潜在的危及生命的疾病,在猫中并不常见。溶栓药物已被描述用于人类和犬类患者治疗这种疾病,特别是在尽管进行了支持性治疗但血流动力学仍持续不稳定的情况下。本报告描述了一只患有肺血栓栓塞的猫的临床过程、超声心动图诊断及成功的溶栓治疗。尽管证实再灌注,但这只猫仍死于血栓栓塞性疾病,凸显了在小动物尤其是猫中对该疾病最佳治疗方法的知识匮乏。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9ff/9067301/54ccb01bf231/fvets-09-851106-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9ff/9067301/54ccb01bf231/fvets-09-851106-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9ff/9067301/54ccb01bf231/fvets-09-851106-g0001.jpg

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本文引用的文献

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Focused Ultrasound of Vascular System in Dogs and Cats-Thromboembolic Disease.犬猫血管系统聚焦超声 - 血栓栓塞性疾病。
Vet Clin North Am Small Anim Pract. 2021 Nov;51(6):1267-1282. doi: 10.1016/j.cvsm.2021.07.013. Epub 2021 Sep 14.
2
Use of tissue plasminogen activator to alleviate postoperative subcutaneous ureteral bypass obstruction secondary to blood clot in seven cats.使用组织型纤溶酶原激活物缓解 7 例猫因血凝块导致的术后皮下输尿管旁路梗阻。
J Feline Med Surg. 2021 Oct;23(10):996-1004. doi: 10.1177/1098612X21991454. Epub 2021 Feb 5.
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2019 ESC Guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS).
2019年欧洲心脏病学会(ESC)与欧洲呼吸学会(ERS)合作制定的急性肺栓塞诊断和管理指南。
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Eur Heart J. 2015 Mar 7;36(10):605-14. doi: 10.1093/eurheartj/ehu218. Epub 2014 Jun 10.
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Comparison of computed tomography pulmonary angiography and point-of-care tests for pulmonary thromboembolism diagnosis in dogs.计算机断层扫描肺动脉造影与即时检验在犬肺血栓栓塞症诊断中的比较
J Small Anim Pract. 2014 Apr;55(4):190-7. doi: 10.1111/jsap.12185. Epub 2014 Feb 13.
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