Landolt A M, Kleihues P, Heitz P U
Arch Pathol Lab Med. 1987 May;111(5):453-8.
Two different types of amyloid deposits in pituitary adenomas are described herein. The deposits of the first type are stellate and perivascular masses, with fibrillary inclusions occurring in the intercellular space. No immunoreactive cytokeratin can be detected in the deposits, and the masses are secreted by the adenoma cells. A second, rarer type is characterized by spheroids (40 to 1500 micron in diameter) in which immunoreactive cytokeratin fibrils are present. The fibrils originate in the adenoma cells adjacent to the deposits. The amyloid nature of both types of deposits can be proved by intense red staining with Congo red, green dichroism, and positive immunostaining with antibodies raised against serum amyloid P component. Adenomas with amyloid spheroids are very rare, and most have been proved or suspected prolactin-producing adenomas.
本文描述了垂体腺瘤中两种不同类型的淀粉样沉积物。第一种类型的沉积物为星状和血管周围团块，纤维状内含物出现在细胞间隙。沉积物中未检测到免疫反应性细胞角蛋白，且这些团块由腺瘤细胞分泌。第二种较罕见的类型的特征是存在球体（直径40至1500微米），其中有免疫反应性细胞角蛋白纤维。这些纤维起源于沉积物附近的腺瘤细胞。两种类型沉积物的淀粉样本质可通过刚果红强烈红色染色、绿色二色性以及用针对血清淀粉样P成分产生的抗体进行阳性免疫染色来证实。有淀粉样球体的腺瘤非常罕见，且大多数已被证实或怀疑为分泌催乳素的腺瘤。
