Zhang Xiaojin, Dai Yu, Dai Guofei, Deng Chunhui
Engineering Research Center of Nano-Geomaterials of Ministry of Education, Faculty of Materials Science and Chemistry, China University of Geosciences Wuhan 430074 China
Jiangxi Provincial Key Laboratory of Water Resources and Environment of Poyang Lake, Jiangxi Institute of Water Sciences Nanchang 330029 China
RSC Adv. 2020 Jun 5;10(36):21602-21614. doi: 10.1039/d0ra03478a. eCollection 2020 Jun 2.
ABC terpolymers are a class of very important polymers because of their expansive molecular topologies and extensive architectures. As block A, poly(ethylene glycol) (PEG) is one of the most principal categories owing to good biocompatibility and wide commercial availability. More importantly, the synthetic approaches of ABC terpolymers using PEG as a macroinitiator are facile and varied. PEG-based ABC terpolymers from design and synthesis to applications are highlighted in this review. Linear, 3-miktoarm, and cyclic polymers as the architecture are separated. The synthetic approaches of PEG-based ABC terpolymers mainly include the sequential polymerization or coupling of polymers. PEG-based ABC terpolymers have wide applications in the fields of drug carriers, gene vectors, templates for the fabrication of inorganic hollow nanospheres, and stabilizers of metal nanoparticles.
ABC三嵌段共聚物是一类非常重要的聚合物，因为它们具有丰富的分子拓扑结构和广泛的架构。作为嵌段A，聚乙二醇（PEG）由于良好的生物相容性和广泛的商业可得性，是最主要的类别之一。更重要的是，以PEG作为大分子引发剂合成ABC三嵌段共聚物的方法简便且多样。本综述重点介绍了基于PEG的ABC三嵌段共聚物从设计、合成到应用的情况。按结构分为线性、三臂星型和环状聚合物。基于PEG的ABC三嵌段共聚物的合成方法主要包括聚合物的顺序聚合或偶联。基于PEG的ABC三嵌段共聚物在药物载体、基因载体、无机空心纳米球制备模板以及金属纳米颗粒稳定剂等领域有广泛应用。
