Dag Aydan, Zhao Jiacheng, Stenzel Martina H
Centre for Advanced Macromolecular Design, School of Chemistry and School of Chemical Engineering, The University of New South Wales, Sydney, NSW 2052, Australia.
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Bezmialem Vakif University, 34093 Fatih, Istanbul, Turkey.
ACS Macro Lett. 2015 May 19;4(5):579-583. doi: 10.1021/acsmacrolett.5b00163. Epub 2015 May 4.
Morphologies, that resemble viruses, were created using a single ABC triblock terpolymer poly(2-acryloylethyl-α-d-mannopyranoside)--poly(-butyl acrylate)--poly(4-vinylpyridine) (PAcManA--PBA--PVP). Morphologies ranging from flower-like micelles, cylindrical micelles, raspberry-like morphologies to nanocaterpillars were obtained by adjusting the pH value during the self-assembly process. The resulting nanoparticles had an abundance of mannose on the surface, which were recognized by the mannose receptors of RAW264.7, a macrophage cell line that can be used as a model for virus entry.
使用单一的ABC三嵌段三元共聚物聚（2-丙烯酰基乙基-α-D-甘露吡喃糖苷）-聚（丙烯酸丁酯）-聚（4-乙烯基吡啶）（PAcManA-PBA-PVP）制备了类似病毒的形态。通过在自组装过程中调节pH值，获得了从花状胶束、圆柱形胶束、覆盆子状形态到纳米毛虫等各种形态。所得纳米颗粒表面有大量的甘露糖，可被RAW264.7细胞系的甘露糖受体识别，RAW264.7细胞系是一种可作为病毒进入模型的巨噬细胞系。
