Zhang Hong-Lian, Zhang Ai-Hua, Miao Jian-Hua, Sun Hui, Yan Guang-Li, Wu Fang-Fang, Wang Xi-Jun
National Engineering Laboratory for the Development of Southwestern Endangered Medicinal Materials, Guangxi Botanical Garden of Medicinal Plant Nanning Guangxi China
Sino-America Chinmedomics Technology Collaboration Center, National TCM Key Laboratory of Serum Pharmacochemistry, Chinmedomics Research Center of State Administration of TCM, Laboratory of Metabolomics, Department of Pharmaceutical Analysis, Heilongjiang University of Chinese Medicine Heping Road 24 Harbin China.
RSC Adv. 2019 Jan 23;9(6):3072-3080. doi: 10.1039/c8ra08520j. eCollection 2019 Jan 22.
Colorectal cancer (CRC) is one of the most malignant cancers resulting from abnormal metabolism alterations. As one of the essential amino acids, tryptophan has a variety of physiological functions, closely related to regulation of immune system, central nervous system, gastrointestinal nervous system and intestinal microflora. Colorectal cancer, a type of high-grade malignancy disease, stems from a variety of factors and often accompanies inflammatory reactions, dysbacteriosis, and metabolic disorders. Colorectal cancer accompanies inflammation and imbalance of intestinal microbiota and affects tryptophan metabolism. It is known that metabolites, rate-limiting enzymes, and ARH in tryptophan metabolism are associated with the development of CRC. Specifically, IDO1 may be a potential therapeutic target in colorectal cancer treatment. Furthermore, the reduction of tryptophan amount is proportional to the poor quality of life for colorectal cancer patients. This paper aims to discuss the role of tryptophan metabolism in a normal organism and investigate the relationship between this amino acid and colorectal cancer. This study is expected to provide theoretical support for research related to targeted therapy for colorectal cancer. Furthermore, strategies that modify tryptophan metabolism, effectively inhibiting tumor progression, may be more effective for CRC treatment.
结直肠癌（CRC）是由异常代谢改变导致的最恶性的癌症之一。色氨酸作为必需氨基酸之一，具有多种生理功能，与免疫系统、中枢神经系统、胃肠神经系统及肠道微生物群的调节密切相关。结直肠癌是一种高度恶性疾病，由多种因素引起，常伴有炎症反应、菌群失调和代谢紊乱。结直肠癌伴随着肠道微生物群的炎症和失衡，并影响色氨酸代谢。已知色氨酸代谢中的代谢产物、限速酶和芳香烃受体与结直肠癌的发生发展有关。具体而言，吲哚胺2,3-双加氧酶1（IDO1）可能是结直肠癌治疗中的一个潜在治疗靶点。此外，色氨酸含量的降低与结直肠癌患者生活质量差成正比。本文旨在探讨色氨酸代谢在正常生物体中的作用，并研究这种氨基酸与结直肠癌之间的关系。本研究有望为结直肠癌靶向治疗相关研究提供理论支持。此外，改变色氨酸代谢、有效抑制肿瘤进展的策略可能对结直肠癌治疗更有效。
