Liu Shengnan, Li Hang, Zhang Jikun, Tian Xin, Li Xinming
College of Chemistry, Chemical Engineering and Materials Science, Soochow University Suzhou 215123 China
State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Soochow University Suzhou 215123 China
RSC Adv. 2020 Sep 11;10(56):33642-33650. doi: 10.1039/d0ra06718k. eCollection 2020 Sep 10.
In recent years, peptide self-assembly proved to be an efficient strategy to create complex structures or functional materials with nanoscale precision. In this work, we designed and synthesized a novel glycopeptide molecule with a galactose moiety through peptide galactosylation. Then relying on peptide self-assembling strategies, we created a supramolecular hydrogel with multivalent galactose ligands on the surface of self-assembled nanofibers for molecular recognition and interactions. Because of multivalent galactose-LecA interactions, the self-assemblies of glycopeptide could target specifically, and acted as anti-virulence and antibacterial agents to inhibit biofilm formation and bacterial growth of . Moreover, in association with polymyxin B, a common antibiotic, the glycopeptide hydrogel exhibited a synergistic growth inhibition effect on biofilm colonization of .
近年来，肽自组装被证明是一种以纳米级精度创建复杂结构或功能材料的有效策略。在这项工作中，我们通过肽糖基化设计并合成了一种带有半乳糖部分的新型糖肽分子。然后依靠肽自组装策略，我们创建了一种超分子水凝胶，在自组装纳米纤维表面带有多价半乳糖配体，用于分子识别和相互作用。由于多价半乳糖与LecA的相互作用，糖肽的自组装可以特异性靶向，并作为抗毒力和抗菌剂抑制生物膜形成和细菌生长。此外，与常见抗生素多粘菌素B联合使用时，糖肽水凝胶对生物膜定植表现出协同生长抑制作用。
