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含精油三元共聚物胶囊的制备及其抗真菌活性评估。

Preparation of terpolymer capsules containing essential oil and evaluation of its antifungal activity.

作者信息

Neves Juliete Silva, Lopes-da-Silva Zita, de Sousa Brito Neta Maria, Chaves Sacha Braun, Karla de Medeiros Nóbrega Yanna, Henrique de Lira Machado Angelo, Machado Fabricio

机构信息

Instituto de Química, Universidade de Brasília, Campus Universitário Darcy Ribeiro CEP 70910-900 Brazil

Faculdade de Ciências da Saúde, Universidade de Brasília, Campus Universitário Darcy Ribeiro CEP 70910-900 Brazil.

出版信息

RSC Adv. 2019 Jul 22;9(39):22586-22596. doi: 10.1039/c9ra02336d. eCollection 2019 Jul 17.

DOI:10.1039/c9ra02336d
PMID:35519452
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9067078/
Abstract

The essential oil from presents antifungal activity and is used in industry as a natural preserving agent. However, essential oils are unstable compounds. So, the encapsulation of essential oils is a technique used to protect it, minimizing degradation and reducing undesired interaction with the other formulation components. Thus, this work focuses on the synthesis of terpolymeric capsules containing essential oil from , aiming to use it as an antifungal component in cosmetics. The capsules were obtained terpolymerization of methyl methacrylate, styrene and methacrylic acid in a dispersed phase polymerization process. The properties of the polymers and the fungicide activity were evaluated. The studied essential oil presented a Minimum Inhibitory Concentration (MIC) ranging from 2.25 to 4.5 mg mL and a Minimum Fungicidal Concentration (MFC) from 4.5 to 9.0 mg mL for strains of , and , and after the encapsulation process, the antifungal activity of the oil was maintained. Additionally, cytotoxicity assays against fibroblast cell lines and human keratinocytes showed that the polymeric nanocapsules containing essential oil can be regarded as a very promising material intended for cosmetics and drug delivery applications.

摘要

[植物名称]的精油具有抗真菌活性，在工业上用作天然防腐剂。然而，精油是不稳定的化合物。因此，精油的包封是一种用于保护它的技术，可将降解降至最低，并减少与其他配方成分的不良相互作用。因此，这项工作专注于合成含有[植物名称]精油的三元聚合物胶囊，旨在将其用作化妆品中的抗真菌成分。通过在分散相聚合过程中使甲基丙烯酸甲酯、苯乙烯和甲基丙烯酸进行三元聚合来获得胶囊。对聚合物的性能和杀真菌活性进行了评估。所研究的精油对[真菌菌株名称1]、[真菌菌株名称2]和[真菌菌株名称3]菌株的最低抑菌浓度（MIC）为2.25至4.5 mg/mL，最低杀菌浓度（MFC）为4.5至9.0 mg/mL，并且在包封过程后，该油的抗真菌活性得以保持。此外，针对成纤维细胞系和人角质形成细胞的细胞毒性试验表明，含有[植物名称]精油的聚合物纳米胶囊可被视为一种非常有前景的材料，适用于化妆品和药物递送应用。

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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e205/9067078/210fdbc90840/c9ra02336d-f11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e205/9067078/cdf7c88b0a7a/c9ra02336d-f12.jpg
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