利用无细胞膜蛋白合成制备阳离子蛋白脂质体：阳离子脂质体的伴侣效应
Preparation of cationic proteoliposomes using cell-free membrane protein synthesis: the chaperoning effect of cationic liposomes.
作者信息
Ando Mitsuru, Sasaki Yoshihiro, Akiyoshi Kazunari
机构信息
Department of Polymer Chemistry, Graduate School of Engineering, Kyoto University Katsura, Nishikyo-ku Kyoto 615-8510 Japan
出版信息
RSC Adv. 2020 Aug 4;10(48):28741-28745. doi: 10.1039/d0ra05825d. eCollection 2020 Aug 3.
Abstract
Membrane protein reconstituted cationic liposomes are constructed using cell-free membrane protein synthesis in the presence of cationic liposomes. The chaperon effect of cationic liposomal membrane assists in folding the functional conformation of membrane protein. This preparation method enables the provision of the usage of proteoliposomes for drug delivery.
摘要
在阳离子脂质体存在的情况下，利用无细胞膜蛋白合成构建膜蛋白重构阳离子脂质体。阳离子脂质体膜的伴侣效应有助于膜蛋白折叠成功能构象。这种制备方法能够提供用于药物递送的蛋白脂质体。
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