Departament d'Enginyeria Química, Universitat Politècnica de Catalunya, EEBE, Av. Eduard Maristany 10-14, 08019 Barcelona, Spain.
Barcelona Research Center in Multiscale Science and Engineering, Universitat Politècnica de Catalunya, Campus Diagonal-Besòs, Av. Eduard Maristany 10-14, 08019 Barcelona, Spain.
Int J Mol Sci. 2023 Feb 8;24(4):3446. doi: 10.3390/ijms24043446.
Lately, there has been an increasing demand for materials that could improve tissue regenerative therapies and provide antimicrobial effects. Similarly, there is a growing need to develop or modify biomaterials for the diagnosis and treatment of different pathologies. In this scenario, hydroxyapatite (HAp) appears as a bioceramic with extended functionalities. Nevertheless, there are certain disadvantages related to the mechanical properties and lack of antimicrobial capacity. To circumvent them, the doping of HAp with a variety of cationic ions is emerging as a good alterative due to the different biological roles of each ion. Among many elements, lanthanides are understudied despite their great potential in the biomedical field. For this reason, the present review focuses on the biological benefits of lanthanides and how their incorporation into HAp can alter its morphology and physical properties. A comprehensive section of the applications of lanthanides-substituted HAp nanoparticles (HAp NPs) is presented to unveil the potential biomedical uses of these systems. Finally, the need to study the tolerable and non-toxic percentages of substitution with these elements is highlighted.
最近，人们对能够改善组织再生治疗并提供抗菌效果的材料的需求日益增加。同样，也越来越需要开发或修饰生物材料，以用于诊断和治疗各种病理。在这种情况下，羟基磷灰石 (HAp) 作为一种具有扩展功能的生物陶瓷出现。然而，其机械性能和缺乏抗菌能力存在一定的缺点。为了克服这些缺点，用各种阳离子掺杂 HAp 作为一种很好的替代方法正在兴起，因为每种离子都具有不同的生物学作用。在许多元素中，尽管镧系元素在生物医学领域具有巨大的潜力，但它们的研究还很不足。出于这个原因，本综述重点介绍了镧系元素的生物学益处，以及它们掺入 HAp 如何改变其形态和物理性质。还介绍了镧系元素取代的 HAp 纳米粒子 (HAp NPs) 的应用的综合部分，以揭示这些系统在生物医学中的潜在用途。最后，强调了需要研究这些元素的可耐受和无毒取代百分比。
