Yan Rulong, Li Xiaoni, Yang Xiaodong, Kang Xing, Xiang Likui, Huang Guosheng
State Key Laboratory of Applied Organic Chemistry, Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, Department of Chemistry, Lanzhou University, Lanzhou, 730000 China.
Chem Commun (Camb). 2015 Feb 14;51(13):2573-6. doi: 10.1039/c4cc08834d.
A novel iodine-mediated oxidative tandem cyclization reaction of simple enaminones has been developed for the synthesis of substituted furopyridines through C-C/C-N/C-O bond formation in a one-pot procedure. Substituted furopyridines are obtained in moderate to good yield. In addition, I- and Br-substituted furopyridines have been successfully produced by the electrophilic substitution of N-iodo- or N-bromosuccinimide.
已经开发了一种新颖的碘介导的简单烯胺酮氧化串联环化反应，用于通过一锅法形成C-C/C-N/C-O键来合成取代的呋喃并吡啶。取代的呋喃并吡啶以中等至良好的产率获得。此外，通过N-碘代或N-溴代琥珀酰亚胺的亲电取代成功制备了I-和Br-取代的呋喃并吡啶。
