Sidorenko A V, Maksiuk T V
Biull Eksp Biol Med. 1987 Apr;103(4):468-70.
Femurs from both young and old mice were implanted subcutaneously to young syngeneic recipients. 2-2.5 months after surgery femoral marrow grafts were repopulated with nucleated cells and macrophage-granulocyte precursor cells irrespective of the donor's age. Marrow depletion of femurs prior to implantation caused a sharp decrease in hemopoietic repopulation of implants from old, but not young, donors. It is concluded that age-dependent functional peculiarities of stromal microenvironment can be visualized owing to the extraordinary local regenerative demand.
将年轻和年老小鼠的股骨皮下植入同基因的年轻受体。术后2至2.5个月，无论供体年龄如何，股骨髓移植物均被有核细胞以及巨噬细胞-粒细胞前体细胞重新填充。植入前对股骨进行骨髓清除，导致年老供体而非年轻供体的植入物造血重建急剧减少。得出的结论是，由于特殊的局部再生需求，可以观察到基质微环境的年龄依赖性功能特性。
