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过去十年中来源于土壤真菌的具有生物活性的新型化合物。

The Novel Compounds with Biological Activity Derived from Soil Fungi in the Past Decade.

机构信息

Gene Engineering and Biotechnology Beijing Key Laboratory, College of Life Science, Beijing Normal University, Beijing, People's Republic of China.

Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, People's Republic of China.

出版信息

Drug Des Devel Ther. 2022 Oct 12;16:3493-3555. doi: 10.2147/DDDT.S377921. eCollection 2022.

DOI:10.2147/DDDT.S377921
PMID:36248243
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9553542/
Abstract

The secondary metabolites isolated from soil fungi have received more and more attention, especially new compounds that exhibited good biological activities. In this review, a total of 546 new compounds are included in the relevant literature since 2011. The new compounds are isolated from soil fungi, We divided these compounds into seven categories, including alkaloids, terpenoids, steroids, ketones, phenylpropanoids, quinones, esters, lactones, etc. In addition, the biological activities and structure-activity relationships of these compounds have also been fully discussed. The activities of these compounds are roughly divided into eight categories, including anticancer activity, antimicrobial activity, anti-inflammatory activity, antioxidant activity, antiviral activity, antimalarial activity, immunosuppressive activity and other activities. Since natural products are an important source of new drugs, this review may have a positive guiding effect on drug screening.

摘要

从土壤真菌中分离出的次生代谢产物受到了越来越多的关注，尤其是具有良好生物活性的新型化合物。在本篇综述中，共纳入了 2011 年以来相关文献中报道的 546 个新化合物。这些化合物均从土壤真菌中分离得到，我们将这些化合物分为 7 个类型，包括生物碱类、萜类、甾体类、酮类、苯丙素类、醌类、酯类、内酯类等。此外，还充分讨论了这些化合物的生物活性和构效关系。这些化合物的活性大致可分为八大类，包括抗癌活性、抗菌活性、抗炎活性、抗氧化活性、抗病毒活性、抗疟活性、免疫抑制活性和其他活性。由于天然产物是新药的重要来源，因此本篇综述可能对药物筛选具有积极的指导作用。

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2
Sesquiterpenes from the soil-derived fungus PSU-SPSF346.来自土壤源真菌PSU-SPSF346的倍半萜类化合物。
Beilstein J Org Chem. 2022 Apr 29;18:479-485. doi: 10.3762/bjoc.18.50. eCollection 2022.
3
Pycnidiophorones A-D, four new cytochalasans from the wetland derived fungus .柄壳孢菌素A-D，四种源自湿地真菌的新细胞松弛素。
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Life (Basel). 2024 Nov 28;14(12):1562. doi: 10.3390/life14121562.
4
Bisindole Compounds-Synthesis and Medicinal Properties.双吲哚化合物——合成与药用特性
Antibiotics (Basel). 2024 Dec 13;13(12):1212. doi: 10.3390/antibiotics13121212.
5
Spent Mushroom Substrate Improves Microbial Quantities and Enzymatic Activity in Soils of Different Farming Systems.废弃菌棒可提高不同种植系统土壤中的微生物数量和酶活性。
Microorganisms. 2024 Jul 24;12(8):1521. doi: 10.3390/microorganisms12081521.
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4
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5
Anti-Diabetic Indole-Terpenoids From sp. HFF16 Isolated From the Rhizosphere Soil of Decne.从Decne根际土壤中分离出的sp. HFF16的抗糖尿病吲哚-萜类化合物。
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6
New phenalenone derivatives from the Hawaiian volcanic soil-associated fungus Penicillium herquei FT729 and their inhibitory effects on indoleamine 2,3-dioxygenase 1 (IDO1).从夏威夷火山土壤相关真菌青霉属 herquei FT729 中分离到的新苯并呋喃酮衍生物及其对吲哚胺 2,3-双加氧酶 1（IDO1）的抑制作用。
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7
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9
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10
Asperanstinoids A-E: Undescribed 3,5-dimethylorsellinic acid-based meroterpenoids from Aspergillus calidoustus.aspergstinoids A-E：青霉属中未被描述的基于 3,5-二甲基奥尔烯酸的混合倍半萜。
Phytochemistry. 2021 Oct;190:112892. doi: 10.1016/j.phytochem.2021.112892. Epub 2021 Jul 31.