从海洋海绵来源真菌土曲霉 SCSIO 41008 中分离得到的肽和聚酮。
Peptides and polyketides isolated from the marine sponge-derived fungus Aspergillus terreus SCSIO 41008.
机构信息
CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China; University of Chinese Academy of Sciences, Beijing 100049, China.
School of Life Sciences, Sun Yat-Sen University, Guangzhou 510275, China; Biomedical Center of Sun Yat-Sen University, Guangzhou 510275, China.
出版信息
Chin J Nat Med. 2019 Feb;17(2):149-154. doi: 10.1016/S1875-5364(19)30017-2.
Two new isomeric modified tripeptides, aspergillamides C and D (compounds 1 and 2), together with fifteen known compounds (compounds 3-17), were obtained from the marine sponge-derived fungus Aspergillus terreus SCSIO 41008. The structures of the new compounds, including absolute configurations, were determined by extensive analyses of spectroscopic data (NMR, MS, UV, and IR) and comparisons between the calculated and experimental electronic circular dichroism (ECD) spectra. Butyrolactone I (compound 11) exhibited strong inhibitory effects against Mycobacterium tuberculosis protein tyrosine phosphatase B (MptpB) with the IC being 5.11 ± 0.53 μmol·L, and acted as a noncompetitive inhibitor based on kinetic analysis.
从海洋海绵来源的真菌曲霉菌 SCSIO 41008 中分离得到了两种新的同型二聚体修饰三肽，即aspergillamides C 和 D（化合物 1 和 2），以及十五种已知化合物（化合物 3-17）。通过对光谱数据（NMR、MS、UV 和 IR）的广泛分析以及计算和实验电子圆二色性（ECD）光谱之间的比较，确定了新化合物的结构，包括绝对构型。丁内酯 I（化合物 11）对结核分枝杆菌蛋白酪氨酸磷酸酶 B（MptpB）表现出强烈的抑制作用，IC 为 5.11±0.53μmol·L，根据动力学分析，它是一种非竞争性抑制剂。
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