磷酸烯醇丙酮酸及其乙烯基醚产物在生物合成中的多功能性。

The versatility of phosphoenolpyruvate and its vinyl ether products in biosynthesis.

作者信息

Walsh C T, Benson T E, Kim D H, Lees W J

机构信息

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA.

出版信息

Chem Biol. 1996 Feb;3(2):83-91. doi: 10.1016/s1074-5521(96)90282-3.

DOI:10.1016/s1074-5521(96)90282-3

PMID:8807832

Abstract

The diverse enzymes that use phosphoenolpyruvate as a substrate lie at the heart of cellular energy metabolism, as well as a number of critical biosynthetic pathways. The versatility of the enol ether linkage is reflected not only in the rich chemistry and enzymology of PEP, but also in the variety of metabolites in which the high-energy enol ether linkage is preserved.

摘要

以磷酸烯醇式丙酮酸为底物的多种酶处于细胞能量代谢以及许多关键生物合成途径的核心位置。烯醇醚键的多功能性不仅体现在磷酸烯醇式丙酮酸丰富的化学性质和酶学特性上，还体现在保留了高能烯醇醚键的多种代谢产物中。