Floris Sonia, Fais Antonella, Rosa Antonella, Piras Alessandra, Marzouki Hanen, Medda Rosaria, González-Paramás Ana M, Kumar Amit, Santos-Buelga Celestino, Era Benedetta
Department of Life and Environmental Sciences, University of Cagliari Monserrato CA Italy
Department of Biomedical Sciences, University of Cagliari Monserrato CA Italy.
RSC Adv. 2019 Jul 8;9(37):21278-21287. doi: 10.1039/c9ra02928a. eCollection 2019 Jul 5.
The chemical composition and biological properties of palm (Lindl.) H. Wendl. seeds are seldom studied. Bearing this in mind, the seeds of fruits were analysed for their fatty acid and phenolic composition and their antioxidant activity in addition to their cholinesterase and xanthine oxidase inhibitory activities. Seed extracts were revealed as a good source of phenolics with significant antioxidant activity. The phenolic profile mainly consisted of proanthocyanidins or procyanidin dimers B1-B4 among the major compounds. The highest butyrylcholinesterase inhibitory activity was found in the ethanolic extracts of seeds, with IC values of 13.73 ± 1.31 μg mL. Seed alcoholic extracts also displayed interesting xanthine oxidase inhibitory activity, with IC values ranging between 75.2 ± 17.0 μg mL and 95.8 ± 5.9 μg mL. Procyanidin B1, a major component in the extracts, could be an important contributor to that activity, as it was found to possess good xanthine oxidase inhibition capacity (IC value of 53.51 ± 6.03 μg mL). Docking studies were also performed to predict the binding sites of procyanidins B1 and B2 within the xanthine oxidase structure. In all, seeds appear as a promising natural source for the extraction of bioactive compounds with antioxidant and butyrylcholinesterase as well as xanthine oxidase inhibitory potential.
棕榈（Lindl.）H. Wendl.种子的化学成分和生物学特性鲜有研究。鉴于此，除了对其胆碱酯酶和黄嘌呤氧化酶抑制活性进行分析外，还对果实种子的脂肪酸、酚类成分及其抗氧化活性进行了分析。种子提取物被证明是酚类物质的良好来源，具有显著的抗氧化活性。酚类成分主要由原花青素或原花青素二聚体B1 - B4等主要化合物组成。种子乙醇提取物中丁酰胆碱酯酶抑制活性最高，IC值为13.73±1.31μg/mL。种子醇提取物还表现出有趣的黄嘌呤氧化酶抑制活性，IC值在75.2±17.0μg/mL至95.8±5.9μg/mL之间。提取物中的主要成分原花青素B1可能是该活性的重要贡献者，因为它被发现具有良好的黄嘌呤氧化酶抑制能力（IC值为53.51±6.03μg/mL）。还进行了对接研究，以预测原花青素B1和B2在黄嘌呤氧化酶结构中的结合位点。总之，种子似乎是提取具有抗氧化、丁酰胆碱酯酶和黄嘌呤氧化酶抑制潜力的生物活性化合物的有前景的天然来源。
