通过去除光不稳定保护基团实现光触发脂质体中亲水性药物的释放。
Light-triggered hydrophilic drug release from liposomes through removal of a photolabile protecting group.
作者信息
Goto Yuya, Ueda Masafumi, Sugikawa Kouta, Yasuhara Kazuma, Ikeda Atsushi
机构信息
Department of Applied Chemistry, Graduate School of Engineering, Hiroshima University 1-4-1 Kagamiyama Higashi-Hiroshima 739-8527 Japan.
School of Science, Kitasato University 1-15-1 Kitasato, Minami-ku Sagamihara Kanagawa 252-0373 Japan.
出版信息
RSC Adv. 2018 Dec 21;9(1):166-171. doi: 10.1039/c8ra08584f. eCollection 2018 Dec 19.
The antibiotic penicillin G cannot be completely incorporated into hydrophobic lipid-membranes owing to its hydrophilicity. Through modification with a hydrophobic and photolabile protecting group, penicillin G was effectively incorporated into liposomes and released by photoirradiation at 365 nm.
由于青霉素G具有亲水性，它无法完全融入疏水性脂质膜中。通过用疏水性且对光不稳定的保护基团进行修饰，青霉素G被有效地包入脂质体中，并在365纳米波长的光照射下释放出来。
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