Xie Bo, Cai Xue, Zhu Yaxin, Sun Zilin, Qiu Shanhu, Wu Tongzhi
Department of General Practice, Zhongda Hospital, Institute of Diabetes, School of Medicine, Southeast University, Nanjing, China.
Research and Education Center of General Practice, Zhongda Hospital, Southeast University, Nanjing, China.
Kardiol Pol. 2022;80(7-8):774-781. doi: 10.33963/KP.a2022.0120. Epub 2022 May 6.
BACKGROUND: Light-intensity physical activity (LPA) is related to a reduced risk of all-cause death in older adults, but its effect on cardiovascular disease or death remains questioned. This meta-analysis aimed to quantify the association of LPA with the risk of cardiovascular disease and death in older adults. METHODS: We conducted a literature search in electronic databases for prospective cohort studies assessing the relationship between LPA measured by accelerometers and the risk of cardiovascular disease and/or death in adults aged ≥60 years. Study-specific hazard ratios (HRs) and 95% confidence intervals (CIs) were pooled using a random effects model. RESULTS: Of the 518 articles identified, 5 prospective cohort studies were included. The mean body mass index of included participants was all over 25 kg/m2. Pooled results showed that the summary HR per 60 min/day higher of LPA was 0.90 (95% CI, 0.83-0.98; n = 3) for the risk of cardiovascular disease and 0.59 (95% CI, 0.49-0.72; n = 2) for cardiovascular death. Both the relationship of LPA with the risk of cardiovascular disease and cardiovascular death were linearly and inversely shaped. The HR for the risk of cardiovascular disease was greater for LPA than for moderate-to-vigorous physical activity (MVPA), in either equal time or equal amount scale (both Pinteraction < 0.01); but the HR for the risk of cardiovascular death was comparable between LPA and MVPA in both scales (both Pinteraction ≥0.20). CONCLUSIONS: Higher LPA is associated with a reduced risk of cardiovascular disease and death in older adults.
背景：低强度体力活动（LPA）与老年人全因死亡风险降低相关，但其对心血管疾病或死亡的影响仍存在疑问。本荟萃分析旨在量化LPA与老年人心血管疾病和死亡风险之间的关联。 方法：我们在电子数据库中检索了前瞻性队列研究，以评估通过加速度计测量的LPA与60岁及以上成年人的心血管疾病和/或死亡风险之间的关系。使用随机效应模型汇总各研究的风险比（HRs）和95%置信区间（CIs）。 结果：在检索到的518篇文章中，纳入了5项前瞻性队列研究。纳入参与者的平均体重指数均超过25kg/m²。汇总结果显示，每天LPA每增加60分钟，心血管疾病风险的汇总HR为0.90（95%CI，0.83 - 0.98；n = 3），心血管死亡风险的汇总HR为0.59（95%CI，0.49 - 0.72；n = 2）。LPA与心血管疾病风险和心血管死亡风险之间的关系均呈线性且负相关。在相等时间或相等运动量尺度下，LPA导致的心血管疾病风险的HR均高于中等至剧烈体力活动（MVPA）（两者P交互作用均<0.01）；但在两种尺度下，LPA和MVPA导致的心血管死亡风险的HR相当（两者P交互作用均≥0.20）。 结论：较高的LPA与老年人心血管疾病和死亡风险降低相关。
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