Department of Endocrinology, Zhongda Hospital, Institute of Diabetes, School of Medicine, Southeast University, Nanjing, China.
Division of Sports and Rehabilitation Medicine, Ulm University Medical Center, Ulm, Germany.
Cancer Epidemiol Biomarkers Prev. 2020 May;29(5):1067-1073. doi: 10.1158/1055-9965.EPI-19-1446. Epub 2020 Apr 17.
The impact of light-intensity physical activity (LPA) in preventing cancer mortality has been questioned. To address this concern, the present meta-analysis aimed to quantify the association between objectively-measured LPA and risk of cancer mortality.
We conducted a systematic literature search in PubMed and Scopus to January 2020. Prospective cohort studies reporting the association between objectively-measured LPA using activity monitors (e.g., accelerometers) and risk of cancer mortality in the general population were included. The summary hazard ratios (HR) per 30 min/day of LPA and 95% confidence intervals (CI) were obtained using a random-effects model. Dose-response analysis was used to plot their relationship.
Five prospective cohort studies were included, in which the definition of LPA based on accelerometer readings was mainly set within 100 to 2,100 counts/min. The summary HR for cancer mortality per 30 min/day of LPA was 0.86 (95% CI, 0.79-0.95; < 1%), and the association between LPA and risk reduction in cancer mortality was linearly shaped ( = 0.72). LPA exhibited a comparable magnitude of risk reduction in cancer mortality of moderate-to-vigorous physical activity regardless of equal time-length (0.87 per 30 min/day vs. 0.94 per 30 min/day, = 0.46) or equal amount (0.74 vs. 0.94 per 150 metabolic equivalents-min/day, = 0.11). Furthermore, replacing sedentary time by LPA of 30 min/day decreased the risk of cancer mortality by 9%.
Objectively-measured LPA conferred benefits in decreasing the risk of cancer mortality.
LPA should be considered in physical activity guidelines to decrease the risk of cancer mortality.
轻度体力活动（LPA）对预防癌症死亡率的影响一直存在争议。为了解决这一问题，本荟萃分析旨在量化客观测量的 LPA 与癌症死亡率风险之间的关系。
我们在 PubMed 和 Scopus 中进行了系统的文献检索，检索时间截至 2020 年 1 月。纳入了使用活动监测仪（如加速度计）客观测量 LPA 与一般人群癌症死亡率之间关联的前瞻性队列研究。使用随机效应模型获得每 30 分钟 LPA 增加 30 分钟/天的汇总风险比（HR）和 95%置信区间（CI）。使用剂量-反应分析来绘制它们之间的关系。
共纳入了 5 项前瞻性队列研究，其中基于加速度计读数的 LPA 定义主要设定在 100 到 2100 计数/分钟之间。LPA 每增加 30 分钟/天，癌症死亡率的汇总 HR 为 0.86（95%CI，0.79-0.95；P<0.001），LPA 与癌症死亡率降低之间的关系呈线性（P<0.001，=0.72）。LPA 与中高强度体力活动在降低癌症死亡率方面具有相当的风险降低作用，无论时间长度相等（每 30 分钟/天增加 0.87 与每 30 分钟/天增加 0.94，P=0.46）还是运动量相等（每 150 代谢当量-分钟/天增加 0.74 与每 150 代谢当量-分钟/天增加 0.94，P=0.11）。此外，将久坐时间替换为 30 分钟/天的 LPA 可使癌症死亡率降低 9%。
客观测量的 LPA 可降低癌症死亡率风险。
LPA 应在体力活动指南中考虑，以降低癌症死亡率风险。
