• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

长链非编码 RNA HOXA10-AS 通过结合 miR-6509-5p 上调胃癌中的 Y 盒结合蛋白 1 发挥癌基因作用。

LncRNA HOXA10-AS functions as an oncogene by binding miR-6509-5p to upregulate Y-box binding protein 1 in gastric cancer.

机构信息

Department of Gastroenterology, First Hospital of Qinhuangdao, Qinhuangdao, Hebei, PR China.

Department of Colorectal Cancer Surgery, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen 361003, Fujian Province, China.

出版信息

Bioengineered. 2022 May;13(5):11373-11387. doi: 10.1080/21655979.2022.2059615.

DOI:10.1080/21655979.2022.2059615
PMID:35521747
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9276040/
Abstract

Gastric cancer (GC) is one of the serious malignant diseases, accounting for several cases globally. The prevention, discovery and cure of GC depend on its molecular mechanism. In recent decades, it has been increasingly recognized that the long noncoding RNAs (lncRNAs) have been involved in GC progression. Therefore, the present study is aimed at identifying relevant lncRNAs that could act as biomarkers for GC prognosis. LncRNA HOXA10-AS is identified to be highly expressed in GC using the ENCORI database. Kaplan-Meier plot analysis indicated that the survival rate of the patient is associated with the expression of lncRNA HOXA10-AS. Interference of HOXA10-AS inhibited GC cell proliferation, migration, and invasion as well as facilitated GC apoptosis. The targets of HOXA10-AS included miR-6509-5p and Y-box binding protein 1 (YBX1). Specifically, HOXA10-AS downregulated miR-6509-5p in GC. An increase of miR-6509-5p inhibited GC cell growth. Meanwhile, miR-6509-5p interacted with YBX1 in GC. Together, lncRNA HOXA10-AS potentially acted as an oncogene through the lncRNA HOXA10-AS/miR-6509-5p/YBX1 signaling pathway in GC.

摘要

胃癌（GC）是一种严重的恶性疾病，占全球病例数的几个。GC 的预防、发现和治疗取决于其分子机制。近几十年来，人们越来越认识到长链非编码 RNA（lncRNAs）参与了 GC 的进展。因此，本研究旨在鉴定可能作为 GC 预后生物标志物的相关 lncRNAs。使用 ENCORI 数据库鉴定到 lncRNA HOXA10-AS 在 GC 中高表达。Kaplan-Meier 绘图分析表明，患者的存活率与 lncRNA HOXA10-AS 的表达有关。HOXA10-AS 的干扰抑制了 GC 细胞的增殖、迁移和侵袭，并促进了 GC 细胞的凋亡。HOXA10-AS 的靶标包括 miR-6509-5p 和 Y 盒结合蛋白 1（YBX1）。具体而言，HOXA10-AS 在 GC 中下调了 miR-6509-5p。miR-6509-5p 的增加抑制了 GC 细胞的生长。同时，miR-6509-5p 在 GC 中与 YBX1 相互作用。总之，lncRNA HOXA10-AS 可能通过 lncRNA HOXA10-AS/miR-6509-5p/YBX1 信号通路在 GC 中发挥癌基因作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5467/9276040/6ce526a26742/KBIE_A_2059615_F0007_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5467/9276040/9ee9dc696073/KBIE_A_2059615_UF0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5467/9276040/647261fba093/KBIE_A_2059615_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5467/9276040/07faa62fe5ce/KBIE_A_2059615_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5467/9276040/c176b40baada/KBIE_A_2059615_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5467/9276040/4928de13d1aa/KBIE_A_2059615_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5467/9276040/3c96bde20c16/KBIE_A_2059615_F0005_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5467/9276040/9d378c12efc5/KBIE_A_2059615_F0006_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5467/9276040/6ce526a26742/KBIE_A_2059615_F0007_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5467/9276040/9ee9dc696073/KBIE_A_2059615_UF0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5467/9276040/647261fba093/KBIE_A_2059615_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5467/9276040/07faa62fe5ce/KBIE_A_2059615_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5467/9276040/c176b40baada/KBIE_A_2059615_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5467/9276040/4928de13d1aa/KBIE_A_2059615_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5467/9276040/3c96bde20c16/KBIE_A_2059615_F0005_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5467/9276040/9d378c12efc5/KBIE_A_2059615_F0006_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5467/9276040/6ce526a26742/KBIE_A_2059615_F0007_OC.jpg

相似文献

1
LncRNA HOXA10-AS functions as an oncogene by binding miR-6509-5p to upregulate Y-box binding protein 1 in gastric cancer.长链非编码 RNA HOXA10-AS 通过结合 miR-6509-5p 上调胃癌中的 Y 盒结合蛋白 1 发挥癌基因作用。
Bioengineered. 2022 May;13(5):11373-11387. doi: 10.1080/21655979.2022.2059615.
2
Downregulation of miR-335-5p by Long Noncoding RNA ZEB1-AS1 in Gastric Cancer Promotes Tumor Proliferation and Invasion.长链非编码RNA ZEB1-AS1对胃癌中miR-335-5p的下调促进肿瘤增殖和侵袭
DNA Cell Biol. 2018 Jan;37(1):46-52. doi: 10.1089/dna.2017.3926. Epub 2017 Dec 7.
3
Silencing of LINC00461 enhances radiosensitivity of lung adenocarcinoma cells by down-regulating HOXA10 via microRNA-195.沉默 LINC00461 通过 microRNA-195 下调 HOXA10 增强肺腺癌细胞的放射敏感性。
J Cell Mol Med. 2020 Mar;24(5):2879-2890. doi: 10.1111/jcmm.14859. Epub 2020 Jan 22.
4
Long noncoding RNA PRKCQ-AS1 promotes CRC cell proliferation and migration via modulating miR-1287-5p/YBX1 axis.长链非编码 RNA PRKCQ-AS1 通过调节 miR-1287-5p/YBX1 轴促进 CRC 细胞增殖和迁移。
J Cell Biochem. 2020 Oct;121(10):4166-4175. doi: 10.1002/jcb.29712. Epub 2020 Jul 3.
5
LncRNA HOXA10-AS Activated by E2F1 Facilitates Proliferation and Migration of Nasopharyngeal Carcinoma Cells Through Sponging miR-582-3p to Upregulate RAB31.E2F1 激活长链非编码 RNA HOXA10-AS 通过海绵吸附 miR-582-3p 促进鼻咽癌细胞的增殖和迁移
Am J Rhinol Allergy. 2022 May;36(3):348-359. doi: 10.1177/19458924211064400. Epub 2022 Jan 24.
6
+HOXA10-AS Promotes Malignant Phenotypes of Gastric Cancer via Upregulating HOXA10.HOXA10-AS 通过上调 HOXA10 促进胃癌的恶性表型。
Comput Math Methods Med. 2022 Feb 16;2022:1846687. doi: 10.1155/2022/1846687. eCollection 2022.
7
Long noncoding RNA LINC00483/microRNA-144 regulates radiosensitivity and epithelial-mesenchymal transition in lung adenocarcinoma by interacting with HOXA10.长链非编码 RNA LINC00483/微小 RNA-144 通过与 HOXA10 相互作用调节肺腺癌的放射敏感性和上皮-间充质转化。
J Cell Physiol. 2019 Jul;234(7):11805-11821. doi: 10.1002/jcp.27886. Epub 2019 Feb 4.
8
Long noncoding RNA SOX2OT contributes to gastric cancer progression by sponging miR-194-5p from AKT2.长链非编码 RNA SOX2OT 通过海绵吸附 AKT2 的 miR-194-5p 促进胃癌进展。
Exp Cell Res. 2018 Aug 15;369(2):187-196. doi: 10.1016/j.yexcr.2018.05.017. Epub 2018 May 18.
9
LncRNA FAM230B Promotes Gastric Cancer Growth and Metastasis by Regulating the miR-27a-5p/TOP2A Axis.长链非编码 RNA FAM230B 通过调控 miR-27a-5p/TOP2A 轴促进胃癌的生长和转移。
Dig Dis Sci. 2021 Aug;66(8):2637-2650. doi: 10.1007/s10620-020-06581-z. Epub 2020 Sep 10.
10
SP1-activated long noncoding RNA lncRNA GCMA functions as a competing endogenous RNA to promote tumor metastasis by sponging miR-124 and miR-34a in gastric cancer.SP1 激活的长非编码 RNA lncRNA GCMA 通过海绵吸附 miR-124 和 miR-34a 在胃癌中作为竞争内源性 RNA 促进肿瘤转移。
Oncogene. 2020 Jun;39(25):4854-4868. doi: 10.1038/s41388-020-1330-4. Epub 2020 May 21.

引用本文的文献

1
LncRNA HOXA10-AS as a novel biomarker and therapeutic target in human cancers.长链非编码RNA HOXA10-AS作为人类癌症中的一种新型生物标志物和治疗靶点。
Front Mol Biosci. 2025 Jan 3;11:1520498. doi: 10.3389/fmolb.2024.1520498. eCollection 2024.
2
The SIX2/PFN2 feedback loop promotes the stemness of gastric cancer cells.SIX2/PFN2 反馈环促进胃癌细胞的干性。
J Transl Med. 2024 Sep 10;22(1):832. doi: 10.1186/s12967-024-05618-5.
3
Ras-related Protein in Brain 4A (Rab4A) is Downregulated by miR-496 to inhibit the Progression of Gastric Cancer.

本文引用的文献

1
LncRNA-SNHG6 promotes the progression of hepatocellular carcinoma by targeting miR-6509-5p and HIF1A.长链非编码RNA-SNHG6通过靶向miR-6509-5p和HIF1A促进肝细胞癌进展。
Cancer Cell Int. 2021 Mar 4;21(1):150. doi: 10.1186/s12935-021-01835-w.
2
FOLFOX Therapy Induces Feedback Upregulation of CD44v6 through YB-1 to Maintain Stemness in Colon Initiating Cells.FOLFOX 疗法通过 YB-1 诱导 CD44v6 的反馈上调，以维持结肠起始细胞的干性。
Int J Mol Sci. 2021 Jan 13;22(2):753. doi: 10.3390/ijms22020753.
3
Assessment of Ki67 in Breast Cancer: Updated Recommendations From the International Ki67 in Breast Cancer Working Group.
脑 Ras 相关蛋白 4A（Rab4A）被 miR-496 下调以抑制胃癌的进展。
Comb Chem High Throughput Screen. 2024;27(18):2734-2740. doi: 10.2174/0113862073260841231010055245.
4
Y-Box Binding Protein 1: Unraveling the Multifaceted Role in Cancer Development and Therapeutic Potential.Y 盒结合蛋白 1：揭开其在癌症发展中的多方面作用及其治疗潜力。
Int J Mol Sci. 2024 Jan 5;25(2):717. doi: 10.3390/ijms25020717.
5
Long noncoding RNA TMEM147-AS1 serves as a microRNA-326 sponge to aggravate the malignancy of gastric cancer by upregulating SMAD5.长链非编码 RNA TMEM147-AS1 通过吸附 microRNA-326 而上调 SMAD5 加剧胃癌的恶性程度。
Oncol Res. 2022 Aug 31;29(4):263-273. doi: 10.32604/or.2022.03568. eCollection 2021.
6
The tip of the iceberg-The roles of long noncoding RNAs in acute myeloid leukemia.冰山一角——长链非编码 RNA 在急性髓系白血病中的作用。
Wiley Interdiscip Rev RNA. 2023 Nov-Dec;14(6):e1796. doi: 10.1002/wrna.1796. Epub 2023 Jun 2.
7
N(6)-methyladenosine-mediated miR-380-3p maturation and upregulation promotes cancer aggressiveness in pancreatic cancer.N(6)-甲基腺苷介导的 miR-380-3p 成熟和上调促进胰腺癌的侵袭性。
Bioengineered. 2022 Jun;13(6):14460-14471. doi: 10.1080/21655979.2022.2088497.
乳腺癌中 Ki67 的评估：国际乳腺癌 Ki67 工作组的最新建议。
J Natl Cancer Inst. 2021 Jul 1;113(7):808-819. doi: 10.1093/jnci/djaa201.
4
Gene regulation by long non-coding RNAs and its biological functions.长非编码 RNA 的基因调控及其生物学功能。
Nat Rev Mol Cell Biol. 2021 Feb;22(2):96-118. doi: 10.1038/s41580-020-00315-9. Epub 2020 Dec 22.
5
Silencing lncRNA HOXA10-AS decreases cell proliferation of oral cancer and HOXA10-antisense RNA can serve as a novel prognostic predictor.沉默长链非编码 RNA HOXA10-AS 可降低口腔癌细胞增殖，HOXA10-反义 RNA 可作为一种新的预后预测因子。
J Int Med Res. 2020 Aug;48(8):300060520934254. doi: 10.1177/0300060520934254.
6
YBX1 mediates autophagy by targeting p110β and decreasing the sensitivity to cisplatin in NSCLC.YBX1 通过靶向 p110β 介导自噬，并降低 NSCLC 对顺铂的敏感性。
Cell Death Dis. 2020 Jun 19;11(6):476. doi: 10.1038/s41419-020-2555-4.
7
Research Progress on Plant Long Non-Coding RNA.植物长链非编码RNA的研究进展
Plants (Basel). 2020 Mar 25;9(4):408. doi: 10.3390/plants9040408.
8
Prognostic 4-lncRNA-based risk model predicts survival time of patients with head and neck squamous cell carcinoma.基于4种长链非编码RNA的预后风险模型预测头颈部鳞状细胞癌患者的生存时间。
Oncol Lett. 2019 Sep;18(3):3304-3316. doi: 10.3892/ol.2019.10670. Epub 2019 Jul 26.
9
Tumor-Promoting Activity of Long Noncoding RNA LINC00466 in Lung Adenocarcinoma via miR-144-Regulated HOXA10 Axis.长非编码 RNA LINC00466 通过 miR-144 调控 HOXA10 轴促进肺腺癌的肿瘤发生活性。
Am J Pathol. 2019 Nov;189(11):2154-2170. doi: 10.1016/j.ajpath.2019.06.014. Epub 2019 Aug 2.
10
HOXA10‑AS: A novel oncogenic long non‑coding RNA in glioma.HOXA10-AS：胶质瘤中一种新型致癌长非编码 RNA。
Oncol Rep. 2018 Nov;40(5):2573-2583. doi: 10.3892/or.2018.6662. Epub 2018 Aug 21.