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Ultrasonics. 2021 Sep;116:106520. doi: 10.1016/j.ultras.2021.106520. Epub 2021 Jul 9.
2
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3
Visualization of Microvascular Angiogenesis Using Dual-Frequency Contrast-Enhanced Acoustic Angiography: A Review.双频对比增强声学血管造影术对微血管新生的可视化研究:综述。
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In Vitro Superharmonic Contrast Imaging Using a Hybrid Dual-Frequency Probe.体外复合双频探头谐波造影成像
Ultrasound Med Biol. 2019 Sep;45(9):2525-2539. doi: 10.1016/j.ultrasmedbio.2019.05.012. Epub 2019 Jun 11.
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Assessment of the Superharmonic Response of Microbubble Contrast Agents for Acoustic Angiography as a Function of Microbubble Parameters.评估微泡造影剂的超声谐波响应作为微泡参数的函数用于声血管造影。
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3-D imaging using row-column-addressed arrays with integrated apodization - part i: apodization design and line element beamforming.使用带有集成变迹功能的行列寻址阵列的三维成像——第一部分:变迹设计与线元波束形成
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A three-mask process for fabricating vacuum-sealed capacitive micromachined ultrasonic transducers using anodic bonding.一种使用阳极键合制造真空密封电容式微机械超声换能器的三掩膜工艺。
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一种基于超宽带电容式微机械超声换能器(CMUT)阵列的手持式声造影成像探头。

A Handheld Imaging Probe for Acoustic Angiography With an Ultrawideband Capacitive Micromachined Ultrasonic Transducer (CMUT) Array.

出版信息

IEEE Trans Ultrason Ferroelectr Freq Control. 2022 Jul;69(7):2318-2330. doi: 10.1109/TUFFC.2022.3172566. Epub 2022 Jun 30.

DOI:10.1109/TUFFC.2022.3172566
PMID:35522635
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9716577/
Abstract

This article presents an imaging probe with a 256-element ultrawideband (UWB) 1-D capacitive micromachined ultrasonic transducer (CMUT) array designed for acoustic angiography (AA). This array was fabricated on a borosilicate glass wafer with a reduced bottom electrode and an additional central plate mass to achieve the broad bandwidth. A custom 256-channel handheld probe was designed and implemented with integrated low-noise amplifiers and supporting power circuitry. This probe was used to characterize the UWB CMUT, which has a functional 3-dB frequency band from 3.5 to 23.5 MHz. A mechanical index (MI) of 0.33 was achieved at 3.5 MHz at a depth of 11 mm. These promising measurements are then combined to demonstrate AA. The use of alternate amplitude modulation (aAM) combined with a frequency analysis of the measured transmit signal demonstrates the suitability of the UWB CMUT for AA. This is achieved by measuring only a low level of unwanted high-frequency harmonics in both the transmit signal and the reconstructed image in the areas other than the contrast bubbles.

摘要

本文提出了一种成像探头,该探头具有 256 个单元的超宽带 (UWB) 1-D 电容式微机械超声换能器 (CMUT) 阵列,专为声血管造影 (AA) 设计。该阵列是在硼硅酸盐玻璃晶圆上制造的,具有减小的底部电极和附加的中央板质量,以实现宽带宽。设计并实现了具有集成低噪声放大器和支持功率电路的定制 256 通道手持式探头。该探头用于表征 UWB CMUT,其功能 3-dB 带宽为 3.5 至 23.5 MHz。在 11mm 深度处,在 3.5 MHz 时实现了 0.33 的机械指数 (MI)。然后将这些有希望的测量结果结合起来进行 AA 演示。使用交替幅度调制 (aAM) 并结合测量的发射信号的频率分析,证明了 UWB CMUT 适用于 AA。这是通过在除对比气泡区域之外的区域中的发射信号和重建图像中仅测量低水平的不需要的高频谐波来实现的。