Faculty of Health Sciences, University of Beira Interior, Covilhã, Portugal.
GRUBI - Systematic Reviews Group, University of Beira Interior, Covilhã, Portugal.
Semin Ophthalmol. 2022 Jul 4;37(5):593-601. doi: 10.1080/08820538.2022.2069471. Epub 2022 May 6.
Pattern Electroretinography (PERG) is a highly sensitive electrophysiological technique used as an indicator of changes in retinal macular area. Amblyopia seems to result from a cortical visual imbalance but changes at the retinal level may also be present. The purpose of this systematic review was to evaluate if there are any consistent changes described in the scientific literature in PERG responses of amblyopic eyes.
Searches were conducted in PubMed and Embase databases, using the keywords "Electroretinography" and "Amblyopia", combined with MeSH or Emtree terms "Pattern Electroretinography", "amblyopia", "PERG" and "amblyopia". PERG P50-N95 amplitude and P50 latency were analysed as well as the methodology used.
A total of 234 articles were found and 6 articles were included for review. One of the articles reported results in adults and five of them in children. One of the articles in children reported no changes in either P50-N95 amplitude or P50 latency. All articles that described differences between the amblyopic eye and the normal eye found a decrease in P50-N95 amplitude and/or a delay in P50 latency.
This review shows promising findings for the use of PERG in amblyopia as an aid in the diagnostic protocol, since this technique may be able to detect an apparent functional impairment of the amblyopic eye.
图形视觉诱发电位（PERG）是一种高度敏感的电生理学技术，可作为视网膜黄斑区域变化的指标。弱视似乎是由于皮质视觉失衡引起的，但视网膜水平也可能存在变化。本系统评价的目的是评估弱视眼 PERG 反应在科学文献中是否有任何一致的变化。
在 PubMed 和 Embase 数据库中使用“Electroretinography”和“Amblyopia”这两个关键词进行搜索，同时使用 MeSH 或 Emtree 术语“Pattern Electroretinography”、“amblyopia”、“PERG”和“amblyopia”进行组合搜索。分析了 PERG P50-N95 振幅和 P50 潜伏期以及所使用的方法。
共发现 234 篇文章，其中 6 篇文章被纳入综述。其中一篇文章报道了成人的结果，五篇文章报道了儿童的结果。其中一篇关于儿童的文章报告称 P50-N95 振幅或 P50 潜伏期均无变化。所有描述弱视眼与正常眼之间差异的文章都发现 P50-N95 振幅降低和/或 P50 潜伏期延迟。
本综述表明 PERG 在弱视诊断中的应用具有很大的前景，因为该技术可能能够检测到弱视眼明显的功能障碍。
