Li Tongxin, Dong Yeqing, Liu Ming, Zhao Jing, Li Minghui, Li Yanzhe
Tianjin Anding Hospital, Tianjin 300222, P. R. China.
Tianjin Mental Health Center, Tianjin 300222, P. R. China.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2022 Apr 25;39(2):370-379. doi: 10.7507/1001-5515.202106051.
There is a shared problem in current optical imaging technologies of how to obtain the optical parameters of biological tissues with complex profiles. In this work, an imaging system for obtaining the optical parameters of biological tissues with complex profile was presented. Firstly, Fourier transformation profilometry was used for obtaining the profile information of biological tissues, and then the difference of incident light intensity at different positions on biological tissue surface was corrected with the laws of illumination, and lastly the optical parameters of biological tissues were achieved with the spatial frequency domain imaging technique. Experimental results indicated the proposed imaging system could obtain the profile information and the optical parameters of biological tissues accurately and quickly. For the slab phantoms with height variation less than 30 mm and angle variation less than 40º, the maximum relative errors of the profile uncorrected optical parameters were 46.27% and 72.18%, while the maximum relative errors of the profile corrected optical parameters were 6.89% and 10.26%. Imaging experiments of a face-like phantom and a human's prefrontal lobe were performed respectively, which demonstrated the proposed imaging system possesses clinical application value for the achievement of the optical parameters of biological tissues with complex profiles. Besides, the proposed profile corrected method can be used to combine with the current optical imaging technologies to reduce the influence of the profile information of biological tissues on imaging quality.
当前光学成像技术存在一个共同问题，即如何获取具有复杂轮廓的生物组织的光学参数。在这项工作中，提出了一种用于获取具有复杂轮廓的生物组织光学参数的成像系统。首先，利用傅里叶变换轮廓术获取生物组织的轮廓信息，然后根据光照定律校正生物组织表面不同位置处入射光强度的差异，最后利用空间频域成像技术获得生物组织的光学参数。实验结果表明，所提出的成像系统能够准确、快速地获取生物组织的轮廓信息和光学参数。对于高度变化小于30毫米且角度变化小于40°的平板模型，未校正轮廓的光学参数的最大相对误差分别为46.27%和72.18%，而校正轮廓的光学参数的最大相对误差分别为6.89%和10.26%。分别对面部模型和人类前额叶进行了成像实验，结果表明所提出的成像系统对于获取具有复杂轮廓的生物组织的光学参数具有临床应用价值。此外，所提出的轮廓校正方法可用于与当前光学成像技术相结合，以减少生物组织轮廓信息对成像质量的影响。
