Lin 林温曼 Wenman, Wei 魏君涵 Junhan, Wang 王文静 Wenjing, Zou 邹李颖 Liying, Zhou 周诗旗 Shiqi, Jiang 江楠 Nan, Reynaud Alexandre, Zhou 周佳玮 Jiawei, Yu 于旭东 Xudong, Hess Robert F
School of Ophthalmology and Optometry and Eye hospital, and State Key Laboratory of Ophthalmology, Optometry and Vision Science, Wenzhou Medical University, Wenzhou, Zhejiang, China, 325000.
Xi'an People's Hospital (Xi'an Fourth Hospital), Shaanxi Eye Hospital, Affiliated Guangren Hospital School of Medicine, Xi'an Jiaotong University, Xi'an 710004, Shaanxi Province, China.
eNeuro. 2022 May 6;9(3). doi: 10.1523/ENEURO.0509-21.2022.
Recent studies show that the human adult visual system exhibits neural plasticity. For instance, short-term monocular deprivation shifts the eye dominance in favor of the deprived eye. This phenomenon is believed to occur in the primary visual cortex by reinstating neural plasticity. However, it is unknown whether the changes in eye dominance after monocularly depriving the visual input can also be induced by alternately depriving both eyes. In this study, we found no changes in binocular balance and interocular correlation sensitivity after a rapid (7 Hz), alternate and monocular deprivation for one hour in adults. Therefore, the effect of short-term monocular deprivation cannot seem to be emulated by alternately and rapidly depriving both eyes.Previous work has shown that short-term binocular function disruption, which its most extreme form is monocular deprivation, could induce neural plasticity in adult visual system. In this study, we found a balanced deprivation of binocular function could not induce a neuroplastic change in human adults. It appears that ocular dominance plasticity in human adults is unique in so far as it is only driven by an input imbalance not balanced deprivation of binocular function.
最近的研究表明，人类成年视觉系统具有神经可塑性。例如，短期单眼剥夺会使眼优势向被剥夺眼转移。这种现象被认为是通过恢复神经可塑性在初级视觉皮层中发生的。然而，单眼剥夺视觉输入后眼优势的变化是否也能通过交替剥夺双眼来诱导尚不清楚。在本研究中，我们发现成年人在快速（7赫兹）、交替和单眼剥夺一小时后，双眼平衡和眼间相关性敏感性没有变化。因此，快速交替剥夺双眼似乎无法模拟短期单眼剥夺的效果。先前的研究表明，短期双眼功能破坏，其最极端的形式是单眼剥夺，可诱导成年视觉系统的神经可塑性。在本研究中，我们发现双眼功能的平衡剥夺不会在成年人类中诱导神经可塑性变化。看来，成年人类的眼优势可塑性是独特的，因为它仅由输入不平衡驱动，而非双眼功能的平衡剥夺。
