Liparoti Giulia, Burchiani Beatrice, Mencaroni Elisabetta, Tripodi Domenico, Di Cara Giuseppe, Verrotti Alberto
Department of Pediatrics, University of Perugia, Perugia, Italy.
Department of Medical, Oral and Biotechnological Sciences, University "G. D'Annunzio"of Chieti-Pescara, Chieti, Italy.
Expert Opin Drug Metab Toxicol. 2022 Mar;18(3):219-233. doi: 10.1080/17425255.2022.2075342. Epub 2022 May 23.
This review aims to identify the optimal therapeutic dosage of anti-epileptic drugs in terms of efficacy and safety in patients with multiple comorbidities.
We have analyzed changes in terms of pharmacokinetics and pharmacodynamics of Brivaracetam, Carbamazepine, Lacosamide, Lamotrigine, Levetiracetam, Topiramate, Valproate, and Zonisamide in liver disease, chronic kidney disease, and in patients admitted to intensive care unit. Our literature search covers the past 5 years. We used PubMed, Google Scholar, and EMBASE database's to support our article.
To ensure that the patient with seizure receives the best treatment in relation to their comorbidities, careful clinical-laboratory monitoring is necessary to maximize effectiveness while maintaining safety, especially in the case of polytherapy.
本综述旨在确定在患有多种合并症的患者中，抗癫痫药物在疗效和安全性方面的最佳治疗剂量。
我们分析了布瓦西坦、卡马西平、拉科酰胺、拉莫三嗪、左乙拉西坦、托吡酯、丙戊酸盐和唑尼沙胺在肝病、慢性肾病以及重症监护病房患者中的药代动力学和药效学变化。我们的文献检索涵盖过去5年。我们使用了PubMed、谷歌学术和EMBASE数据库来支持我们的文章。
为确保癫痫患者针对其合并症接受最佳治疗，需要仔细的临床实验室监测，以在维持安全性的同时最大化有效性，尤其是在联合治疗的情况下。
