The homeostatic γc cytokines IL-7 and IL-15 suppress the induction of CD4CD8αα intraepithelial T cells in the gut.
作者信息
Li Can, Prakhar Praveen, Park Jung-Hyun
机构信息
Experimental Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
出版信息
Cell Mol Immunol. 2022 Jun;19(6):751-753. doi: 10.1038/s41423-022-00868-z. Epub 2022 May 6.
Abstract
摘要
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The homeostatic γc cytokines IL-7 and IL-15 suppress the induction of CD4CD8αα intraepithelial T cells in the gut.
Cell Mol Immunol. 2022 Jun;19(6):751-753. doi: 10.1038/s41423-022-00868-z. Epub 2022 May 6.
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Niche-specific MHC II and PD-L1 regulate CD4+CD8αα+ intraepithelial lymphocyte differentiation.特异性 MHC II 和 PD-L1 调节 CD4+CD8αα+上皮内淋巴细胞分化。
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2
CD4CD8αα IELs: They Have Something to Say.CD4CD8αα IELs：他们有话要说。
Front Immunol. 2019 Oct 9;10:2269. doi: 10.3389/fimmu.2019.02269. eCollection 2019.
3
Intestinal Intraepithelial Lymphocytes: Sentinels of the Mucosal Barrier.肠上皮内淋巴细胞：黏膜屏障的哨兵。
Trends Immunol. 2018 Apr;39(4):264-275. doi: 10.1016/j.it.2017.11.003. Epub 2017 Dec 5.
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The common γ-chain cytokine receptor: tricks-and-treats for T cells.常见的γ链细胞因子受体：T细胞的“ tricks-and-treats”
Cell Mol Life Sci. 2016 Jan;73(2):253-69. doi: 10.1007/s00018-015-2062-4. Epub 2015 Oct 14.
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CD8αα⁺ innate-type lymphocytes in the intestinal epithelium mediate mucosal immunity.肠道上皮中的CD8αα⁺天然型淋巴细胞介导黏膜免疫。
Immunity. 2014 Sep 18;41(3):451-464. doi: 10.1016/j.immuni.2014.08.010. Epub 2014 Sep 11.
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Transcription factor T-bet regulates intraepithelial lymphocyte functional maturation.转录因子T-bet调节上皮内淋巴细胞的功能成熟。
Immunity. 2014 Aug 21;41(2):244-56. doi: 10.1016/j.immuni.2014.06.017.
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The transcription factor T-bet is induced by IL-15 and thymic agonist selection and controls CD8αα(+) intraepithelial lymphocyte development.转录因子 T-bet 由 IL-15 和胸腺激动剂选择诱导，并控制 CD8αα(+)上皮内淋巴细胞的发育。
Immunity. 2014 Aug 21;41(2):230-43. doi: 10.1016/j.immuni.2014.06.018.
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Mutual expression of the transcription factors Runx3 and ThPOK regulates intestinal CD4⁺ T cell immunity.转录因子 Runx3 和 ThPOK 的相互表达调节肠道 CD4⁺ T 细胞免疫。
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Transcriptional reprogramming of mature CD4⁺ helper T cells generates distinct MHC class II-restricted cytotoxic T lymphocytes.成熟 CD4⁺辅助性 T 细胞的转录重编程产生了具有独特 MHC Ⅱ类限制的细胞毒性 T 淋巴细胞。
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