牙周炎与老年中国男性人群前列腺特异性抗原水平的相关性。

Correlation between periodontitis and prostate-specific antigen levels in the elderly Chinese male population.

机构信息

Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Hangzhou, 310006, China.

出版信息

BMC Oral Health. 2022 May 6;22(1):163. doi: 10.1186/s12903-022-02171-9.

DOI:10.1186/s12903-022-02171-9

PMID:35524291

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9074280/

Abstract

BACKGROUND

The comparison of prostate-specific antigen (PSA) levels among older individuals with different periodontal statuses has not been fully investigated. Here we aimed to explore the correlation between the staging and grading of periodontitis and PSA levels in an elderly Chinese male population, which may lead to a biopsy recommendation and prevent prostate cancer as early as possible.

METHODS

The study included 996 individuals aged ≥ 55 years who participated in routine postretirement physical examinations. Periodontal data included probing depth and gingival recession on four sites/tooth and on two diagonal quadrants (1-3 or 2-4) while excluding third molars, and clinical attachment loss was calculated. Periodontal status was classified as none, mild-moderate or severe periodontitis according to the Centers for Disease Control and Prevention and the American Academy of Periodontology case definition. Blood samples, oral health status and sociodemographic characteristics were collected by using general and oral examinations and questionnaires. Linear and logistic regressions were used to estimate the correlation between periodontitis severity and PSA levels, respectively.

RESULTS

A total of 479 men had mild-moderate periodontitis and 355 had severe periodontitis; 162 men were periodontally healthy individuals. After adjusting for potential confounders, PSA levels were significantly lower in the individuals without periodontitis than in those with mild-moderate (P = 0.04) or severe (P = 0.03) periodontitis. However, PSA levels did not significantly correlate with periodontitis severity (P = 0.06). Although the ORs of elevated PSA were not significant, individuals with PSA ≥ 4.0 ng/mL were more likely to have periodontitis.

CONCLUSIONS

In a sample of an elderly Chinese male population, after adjusting for possible confounders, serum PSA levels in individuals with periodontitis were significantly higher than those in individuals without periodontitis, but serum PSA did not significantly correlate with periodontitis severity.

摘要

背景

不同牙周状况的老年个体之间的前列腺特异性抗原（PSA）水平比较尚未得到充分研究。本研究旨在探讨中国老年男性人群中牙周炎分期和分级与 PSA 水平之间的相关性，以期为前列腺活检提供建议，并尽早预防前列腺癌。

方法

本研究纳入了 996 名年龄≥55 岁的参加常规退休后体检的个体。牙周数据包括四个位点/牙齿和两个对角象限（1-3 或 2-4）的探诊深度和牙龈退缩，同时排除第三磨牙，并计算临床附着丧失。根据美国疾病控制与预防中心和美国牙周病学会的病例定义，牙周状况分为无、轻度-中度或重度牙周炎。通过一般和口腔检查以及问卷调查收集血液样本、口腔健康状况和社会人口学特征。使用线性和逻辑回归分别估计牙周炎严重程度与 PSA 水平之间的相关性。

结果

共有 479 名男性患有轻度-中度牙周炎，355 名男性患有重度牙周炎，162 名男性为牙周健康个体。在调整了潜在混杂因素后，无牙周炎个体的 PSA 水平明显低于轻度-中度（P=0.04）或重度（P=0.03）牙周炎个体。然而，PSA 水平与牙周炎严重程度无显著相关性（P=0.06）。虽然 PSA 升高的 OR 不显著，但 PSA≥4.0ng/mL 的个体更有可能患有牙周炎。