Harrison R F, Brennan M
Curr Med Res Opin. 1987;10(6):364-9. doi: 10.1185/03007998709111104.
Aerosol formulations of lignocaine (5%) and cinchocaine (2%) were compared with a water-only placebo spray in a single-dose study in 76 primiparous patients complaining of moderate or severe post-episiotomy pain. In comparison with a water-only placebo, both local anaesthetic formulations gave significant relief when administered to the perineal wound but the lignocaine spray proved to be the more effective. The only side-effect reported was slight stinging occurring immediately after administration of the lignocaine spray in 2 cases. Serum concentrations of local anaesthetic post-administration were negligible. An interesting finding was that breast-feeding patients responded less well to this form of analgesia than patients in whom lactation had been suppressed with frusemide.
在一项单剂量研究中,将利多卡因(5%)和辛可卡因(2%)的气雾剂配方与仅用水的安慰剂喷雾剂进行了比较,研究对象为76名初产妇,她们均抱怨有中度或重度会阴切开术后疼痛。与仅用水的安慰剂相比,两种局部麻醉剂配方用于会阴伤口时均能显著减轻疼痛,但事实证明利多卡因喷雾剂更有效。报告的唯一副作用是2例患者在使用利多卡因喷雾剂后立即出现轻微刺痛。给药后局部麻醉剂的血清浓度可忽略不计。一个有趣的发现是,与用速尿抑制泌乳的患者相比,母乳喂养的患者对这种镇痛方式的反应较差。