Oswaldo Cruz Foundation (Fiocruz, Ceará), Eusébio-CE, Brazil.
Post-Graduate Program in Pharmaceutical Sciences, Federal University of Ceará (UFC), Fortaleza-CE, Brazil.
Curr Med Chem. 2022;29(32):5358-5368. doi: 10.2174/0929867329666220507011719.
In a scenario of increased pathogens with multidrug resistance phenotypes, it is necessary to seek new pharmacological options. This fact is responsible for an increase in neoplasms and multiresistant parasitic diseases. In turn, snake venom- derived peptides exhibited cytotoxic action on fungal and bacterial strains, possibly presenting activities in resistant tumor cells and parasites. Therefore, the aim of this work is to verify an antitumor and antiparasitic activity of antimicrobial peptides derived from snake venom.
For this purpose, searches were performed in the Pubmed, Embase and Virtual Health Library databases by combining the descriptors peptides, venom and snake with antitumor/ antiparasitic agent and in silico. The inclusion criteria: in vitro and in vivo experimental articles in addition to in silico studies. The exclusion criteria: articles that were out of scope, review articles, abstracts, and letters to the reader. Data extracted: peptide name, peptide sequence, semi-maximal inhibitory concentration, snake species, tumor lineage or parasitic strain, cytotoxicity, in vitro and in vivo activity.
In total 164 articles were found, of which 14 were used. A total of ten peptides with antiproliferative activity on tumor cells were identified. Among the articles, seven peptides addressed the antiparasitic activity.
In conclusion, snake venom-derived peptides can be considered as potential pharmacological options for parasites and tumors, however more studies are needed to prove their specific activity.
在具有多种耐药表型的病原体增多的情况下，有必要寻求新的药理选择。这一事实导致了肿瘤和多耐药寄生虫病的增加。反过来，蛇毒衍生肽对真菌和细菌菌株表现出细胞毒性作用，可能对耐药肿瘤细胞和寄生虫具有活性。因此，本工作旨在验证来源于蛇毒的抗菌肽的抗肿瘤和抗寄生虫活性。
为此，通过将描述符肽、毒液和蛇与抗肿瘤/抗寄生虫剂和计算机结合，在 Pubmed、Embase 和虚拟健康图书馆数据库中进行了搜索。纳入标准：除计算机研究外，还包括体外和体内实验性文章。排除标准：范围外的文章、综述文章、摘要和读者来信。提取的数据：肽名称、肽序列、半最大抑制浓度、蛇种、肿瘤谱系或寄生虫株、细胞毒性、体外和体内活性。
共发现 164 篇文章，其中 14 篇被使用。总共鉴定出十种对肿瘤细胞具有增殖活性的肽。在这些文章中，有 7 篇涉及抗寄生虫活性。
总之，蛇毒衍生肽可被视为寄生虫和肿瘤的潜在药理选择，但需要更多的研究来证明其特异性活性。
