Department of Non-communicable Disease Prevention and Control, Shenzhen Luohu Center for Chronic Disease Control, Shenzhen, China.
Department of Comprehensive Ward, Shenzhen Luohu Hospital of Traditional Chinese Medicine, Shenzhen, China.
J Nutr. 2022 Oct 6;152(10):2227-2237. doi: 10.1093/jn/nxac105.
Recent studies have reported conflicting associations between egg consumption and the risk of all-cause or cardiovascular disease (CVD) mortality, including ischemic heart disease (IHD) mortality and stroke mortality. With accumulating evidence, up-to-date evidence about the association should be synthesized.
We aimed to assess the association of the risk of all-cause and CVD mortality with egg consumption.
We searched the PubMed, Embase, and Web of Science databases through 3 November, 2021 for observational studies conducted in participants ≥18 y of age and which provided ORs, RRs, or HRs and 95% CIs for ≥3 egg consumption categories or for increased intake of egg addressing the associations of interest. A random-effects model was used to pool the reported risk estimates. Restricted cubic splines were used to examine the dose-response association.
Twenty-four articles with 48 reports (25 for all-cause mortality, 11 for CVD mortality, 6 for IHD mortality, and 6 for stroke mortality) involving 11,890,695 participants were included. Intake of each 1-egg/d increment was associated with increased risk of all-cause mortality (RR: 1.06; 95% CI: 1.02, 1.10; P = 0.008), but the association was restricted to women, Americans, and studies with adjustments for hyperlipidemia. Egg consumption was linearly associated with CVD mortality only in participants >60 y of age, Americans, studies with follow-up duration ≥15 y, and studies with adjustments for hyperlipidemia (P ≤ 0.018). No significant association was found between egg consumption and IHD or stroke mortality (P ≥ 0.080).
Egg consumption was linearly associated with a modestly increased risk of all-cause mortality and, in older participants, Americans, and studies with longer follow-up or adjustments for hyperlipidemia, CVD mortality. These findings suggest that it may be prudent to avoid high egg consumption.
最近的研究报告称，鸡蛋摄入量与全因或心血管疾病（CVD）死亡率之间的关联存在冲突，包括缺血性心脏病（IHD）死亡率和中风死亡率。随着证据的积累，应该综合最新的关联证据。
我们旨在评估鸡蛋摄入与全因和 CVD 死亡率风险之间的关联。
我们通过 2021 年 11 月 3 日检索了 PubMed、Embase 和 Web of Science 数据库，以获取在年龄≥18 岁的参与者中进行的观察性研究，这些研究提供了 OR、RR 或 HR 以及≥3 个鸡蛋摄入量类别或增加鸡蛋摄入量的报告风险估计值，用于评估相关关联。使用随机效应模型汇总报告的风险估计值。使用限制性立方样条检查剂量反应关联。
共纳入 24 篇文章，涉及 48 份报告（25 份全因死亡率，11 份 CVD 死亡率，6 份 IHD 死亡率，6 份中风死亡率），共涉及 11890695 名参与者。每增加 1 个鸡蛋/天的摄入量与全因死亡率风险增加相关（RR：1.06；95%CI：1.02，1.10；P=0.008），但该关联仅限于女性、美国人以及调整了高脂血症的研究。仅在年龄>60 岁的参与者、美国人、随访时间≥15 年的研究以及调整了高脂血症的研究中，鸡蛋摄入量与 CVD 死亡率呈线性相关（P≤0.018）。未发现鸡蛋摄入量与 IHD 或中风死亡率之间存在显著关联（P≥0.080）。
鸡蛋摄入量与全因死亡率的适度增加呈线性相关，在年龄较大的参与者、美国人以及随访时间较长或调整了高脂血症的研究中，与 CVD 死亡率相关。这些发现表明，避免高鸡蛋摄入量可能是谨慎的。
