General Surgery Department, Kasralainy School of Medicine, Cairo University, Cairo, 12613, Egypt.
Obes Surg. 2022 Jul;32(7):2397-2402. doi: 10.1007/s11695-022-06091-z. Epub 2022 May 7.
Obesity is a risk factor for chronic kidney disease and albuminuria. Despite the well-documented obesity association with diabetes mellitus and hypertension, its predisposition to albuminuria is not related to these comorbidities, and, in some times, its occurrence is independent of DM or hypertension.
The present study aimed to evaluate bariatric surgery effect on albuminuria in patients with severe obesity with no DM or hypertension.
The study consisted of 137 patients with extreme obesity and albuminuria scheduled for bariatric surgery and did not have diabetes or hypertension. They underwent an assessment for 24-h urinary albumin at baseline (T0) and 6 months postoperatively (T2).
Albuminuria remission occurred in 83% of patients; there was a statistically highly significant difference between the baseline and the 6-month postoperative in the 24-h urinary albumin assessment. Weight loss and BMI at T2 were independent predictors of albuminuria remission.
The current work emphasizes the importance and promising role of bariatric surgery as an effective weight reduction management method in improving albuminuria, an early sign of chronic kidney disease, and a potential risk factor for cardiovascular disease.
肥胖是慢性肾脏病和白蛋白尿的一个危险因素。尽管有大量文献证明肥胖与糖尿病和高血压有关，但它导致白蛋白尿的倾向与这些合并症无关，而且在某些情况下，它的发生与糖尿病或高血压无关。
本研究旨在评估肥胖症患者在没有糖尿病或高血压的情况下进行减重手术对白蛋白尿的影响。
该研究包括 137 名患有严重肥胖症和白蛋白尿的患者，他们计划接受减重手术，并且没有糖尿病或高血压。他们在基线（T0）和术后 6 个月（T2）进行了 24 小时尿白蛋白评估。
83%的患者出现了白蛋白尿缓解；24 小时尿白蛋白评估在基线和术后 6 个月之间有统计学上的显著差异。T2 时的体重减轻和 BMI 是白蛋白尿缓解的独立预测因素。
目前的研究强调了减重手术作为一种有效的体重管理方法，在改善白蛋白尿（慢性肾脏病的早期标志和心血管疾病的潜在危险因素）方面的重要性和前景。
