Liu Yuan, Huang Liping, Zeng Yi, Li Mingyang, Xie Huiqi, Shen Bin
Orthopedics Research Institute, Department of Orthopedics, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, 610041, China.
Laboratory of Stem Cell and Tissue Engineering, Orthopedic Research Institute, Med-X Center for Materials, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China.
Sci China Life Sci. 2022 Oct;65(10):1959-1970. doi: 10.1007/s11427-021-2090-3. Epub 2022 May 5.
Autologous fat-derived stromal vascular fraction (SVF) is a mixed cell population that has been used for many years in regenerative plastic surgery. In terms of animal and clinical research, this concise review was performed to evaluate the efficacy of SVF in knee degenerative joint disease (KDJD), which could cause pain, disability and severely affect patients' lives. Thirteen studies retrieved and screened from the databases were included, including six animal studies and seven clinical trials. The meta-analysis of clinical research shows that intra-articular injection of SVF, in combination with adjuvant surgery, could alleviate pain and improve early functional recovery for patients with KDJD at Kellgren-Lawrence (KL) grades II-III.
自体脂肪来源的基质血管成分（SVF）是一种混合细胞群体，多年来一直用于再生整形外科。就动物和临床研究而言，进行了这项简要综述，以评估SVF在膝关节退行性关节疾病（KDJD）中的疗效，该疾病可导致疼痛、残疾并严重影响患者生活。从数据库中检索并筛选出13项研究，包括6项动物研究和7项临床试验。临床研究的荟萃分析表明，关节内注射SVF联合辅助手术，可缓解疼痛，并改善Kellgren-Lawrence（KL）分级为II-III级的KDJD患者的早期功能恢复。
