Laboratory for Rigenerative Orthopaedics, Research Unit of Orthopaedic and Trauma Surgery, Departmental Faculty of Medicine and Surgery, Campus Bio-Medico University of Rome (UCBM), Rome, Italy.
J Biol Regul Homeost Agents. 2020 Sep-Oct;34(5 Suppl. 1):113-119. IORS Special Issue on Orthopedics.
In recent years, the interest in stromal vascular fraction (SVF) therapy for conservative treatment of osteoarthritis has grown significantly. This study aims to assess three different processing systems (micro-fragmentation, filtration, or slow centrifugation) in terms of cell proliferation in vitro and clinical results of intraarticular injections for the treatment of knee OA. From December 2017 to June 2018, 25 procedures were performed using three different systems. A considerable improvement of the clinical condition in almost all patients already one month after the treatment with a stable effect at 6 and 12 months was recorded. Patients treated with SVF, obtained by the micro-fragmentation system, had better outcomes one month after the treatment with a mean improvement of the symptomatology higher than that found in patients treated with the filtration or slow centrifugation system. The SVF product from the same system had a higher cell proliferation capacity in vitro.
近年来，人们对基质血管成分 (SVF) 治疗骨关节炎的保守治疗方法产生了浓厚的兴趣。本研究旨在评估三种不同的处理系统（微粉碎、过滤或缓慢离心）在体外细胞增殖和关节内注射治疗膝骨关节炎的临床结果方面的差异。2017 年 12 月至 2018 年 6 月，使用三种不同的系统进行了 25 例手术。几乎所有患者在治疗后一个月内临床状况均有明显改善，6 个月和 12 个月时效果稳定。采用微粉碎系统获得的 SVF 治疗的患者，在治疗后一个月的效果更好，其症状改善程度明显高于采用过滤或缓慢离心系统治疗的患者。同一系统的 SVF 产品在体外具有更高的细胞增殖能力。
