School of Public Health, Faculty of Health, University of Technology Sydney, Level 8, Building 10, 235-253 Jones Street, Sydney, NSW 2007, Australia.
School of Public Health, Faculty of Health, University of Technology Sydney, Level 8, Building 10, 235-253 Jones Street, Sydney, NSW 2007, Australia.
J Stroke Cerebrovasc Dis. 2022 Jul;31(7):106543. doi: 10.1016/j.jstrokecerebrovasdis.2022.106543. Epub 2022 May 4.
Stroke is a common cause of mortality and morbidity which affects approximately 17 million people globally each year. Common symptoms associated with stroke are physical disabilities, impaired cognitive functions, depression, and fatigue, all of which can significantly impact health-related quality of life (HRQoL). To date, no research has explored the inter-relationship among fatigue, disability, depression, health-related hardiness, and quality of life in stroke survivors.
Data was obtained from a sub-study of the 45 and Up Study; including 576 Australian adults who had been diagnosed with a stroke. The cross-sectional questionnaire obtained demographic and health status information, as well as clinical measures and stroke-related measures. Associations among fatigue and disability, depression, health-related hardiness and quality of life were analysed using a linear regression model.
In comparison to those participants with no stroke-related disability, those with slight (β = 1.141; p = 0.008), moderate (β = 3.250; p < 0.001) or severe (β = 3.526; p < 0.001) disability had significantly higher fatigue scores. For every one unit increase in the depression score, the fatigue score increased by 1.502 points (p < 0.001). For every one unit increase in the health-related hardiness score, the fatigue score decreased by 0.054 points (p = 0.044). For every one unit increase in the quality of life score, the fatigue score decreased by 0.068 points (p < 0.001).
This study found significant associations among fatigue and disability, depression, health-related hardiness, and quality of life in stroke survivors. Accurate detection and management of fatigue may help improve the rehabilitation of stroke survivors.
中风是一种常见的死亡和发病原因，每年在全球影响约 1700 万人。与中风相关的常见症状包括身体残疾、认知功能受损、抑郁和疲劳，所有这些都会严重影响健康相关生活质量（HRQoL）。迄今为止，尚无研究探讨中风幸存者中疲劳、残疾、抑郁、健康相关坚韧和生活质量之间的相互关系。
数据来自 45 岁及以上研究的子研究；包括 576 名澳大利亚成年人，他们被诊断出患有中风。横断面问卷获取了人口统计学和健康状况信息，以及临床测量和与中风相关的测量。使用线性回归模型分析疲劳和残疾、抑郁、健康相关坚韧和生活质量之间的关联。
与那些没有中风相关残疾的参与者相比，那些有轻微（β=1.141；p=0.008）、中度（β=3.250；p<0.001）或严重（β=3.526；p<0.001）残疾的参与者疲劳评分显著更高。抑郁评分每增加一个单位，疲劳评分增加 1.502 分（p<0.001）。健康相关坚韧评分每增加一个单位，疲劳评分降低 0.054 分（p=0.044）。生活质量评分每增加一个单位，疲劳评分降低 0.068 分（p<0.001）。
本研究发现中风幸存者中疲劳与残疾、抑郁、健康相关坚韧和生活质量之间存在显著关联。准确检测和管理疲劳可能有助于改善中风幸存者的康复。
