Department of Cardiology, Xi'an No.3 Hospital, School of Life Sciences and Medicine, Northwest University, Xi'an, China; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education. School of Life Sciences and Medicine, Northwest University, Xi'an, China.
Department of Cardiology, Xi'an No.3 Hospital, School of Life Sciences and Medicine, Northwest University, Xi'an, China.
Ageing Res Rev. 2022 Aug;79:101638. doi: 10.1016/j.arr.2022.101638. Epub 2022 May 5.
Aging-related diseases such as cancer, cardiovascular diseases, diabetes, and neurodegenerative diseases are often accompanied by fibrosis. The NLRP3 inflammasome triggers the inflammatory response and subsequently promotes fibrosis through pathogen-associated molecular patterns (PAMPs). In this review, we first introduce the general background and specific mechanism of NLRP3 in fibrosis. Second, we investigate the role of NLRP3 in fibrosis in different organs/tissues. Third, we discuss the relationship between NLRP3 and fibrosis during aging. In summary, this review describes the latest progress on the roles of NLRP3 in fibrosis and aging and reveals the possibility of NLRP3 as an antifibrotic and anti-aging treatment target.
与衰老相关的疾病，如癌症、心血管疾病、糖尿病和神经退行性疾病，通常伴随着纤维化。NLRP3 炎性小体通过病原体相关分子模式 (PAMPs) 触发炎症反应，进而促进纤维化。在这篇综述中，我们首先介绍了 NLRP3 在纤维化中的一般背景和具体机制。其次，我们研究了 NLRP3 在不同器官/组织纤维化中的作用。第三，我们讨论了 NLRP3 在衰老过程中与纤维化的关系。总之，本综述描述了 NLRP3 在纤维化和衰老中的作用的最新进展，并揭示了 NLRP3 作为抗纤维化和抗衰老治疗靶点的可能性。
